Results 41 to 50 of about 33,089 (310)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Case with Traumatic Optic Neurpathy: When, What to Do?

Journal of Pediatric Emergency and Intensive Care Medicine, 2021
Traumatic optic neuropathy (TON) is characterized by impaired visual function due to acute damage to the optic nerve injury related to the trauma. The predictive incidence of TON in children and adolescence is 0.7-2.5% after blunt or penetrating head ...
Hasan Özen, Edin Botan, Emrah Gün, Anar Gurbanov, Burak Balaban, Fevzi Kahveci, Huban Atilla, Ömer Suat Fitoz, Tanıl Kendirli   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Transplanted olfactory ensheathing cells promote regeneration of cut adult rat optic nerve axons [PDF]

, 2003
Transplantation of olfactory ensheathing cells into spinal cord lesions promotes regeneration of cut axons into terminal fields and functional recovery.
Li, D., Li, Y., Lund, R.D., Raisman, G., Sauvé, Y.   +4 more
core  

Sarcoidosis of the hypothalamus and pituitary stalk [PDF]

, 1992
We report a rare case of sarcoidosis of the hypothalamic and suprasellar region, with clinical course and the magnetic resonance imaging follow ...
BE Kendall, BJ Stern, Claudia Vogl, CN Linden, DL Veseley, Joachim Stemmler, Josef Lissner, LD Reed, M Brant-Zawadzki, MV Spagnoli, P Delaney, Peter C. Scriba, Thomas J. Voglt, W Ricker, WC Wiederholt, WS Hayes   +15 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Characterizing liability for cranial nerve injuries: A detailed analysis of 209 malpractice trials [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97521/1/lary23995 ...
Eloy, Jean Anderson, Keeley, Brieze R., Kovalerchik, Olga, Mauro, Andrew C., Sunaryo, Peter L., Svider, Peter F.   +5 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Celebration to Consequence: Case Report of Late Onset Ocular Effects of Firework Injuries

Journal of Karnali Academy of Health Sciences
Firework-related injuries, particularly ocular trauma, pose a significant public health concern during cultural celebrations. We explore the case of a 20-year-old male who sustained firework-induced ocular trauma at the age of seven, subsequently ...
Sudha Ranabhat, Saurya Pahadi, Raghunandan Byanju   +2 more
doaj   +3 more sources

Variation of Optic Nerve Types in Different Age Quartiles on Two Sides Based on Delano's Classification of Optic Nerve using Computerized Tomography: A Single Center Cross-Sectional Study in Karachi

Life and Science
Objective: To understand the anatomy of the sphenoid sinus and its associated structures, especially the variations of the optic nerve, to avoid any surgical trauma. Study Design: Cross-sectional study.
Mubina Lakhani, Iffat Raza, Sahrish Mukhtar, Madeeha Sadiq, Sana Azwar, Nuzhat Hassan   +5 more
doaj   +1 more source