Results 61 to 70 of about 16,836 (256)

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Gut microbiota regulates optic nerve fiber myelination

Frontiers in Cell and Developmental Biology
IntroductionRecent evidence supports the hypothesis of an association between gut microbiota and the pathogenesis of retinal and eye diseases, suggesting the existence of a gut-eye axis.
Giulia Ronchi, Davide Pellegrino, Marwa El Soury, Olga Amato, Francesco Gaia, Sajjad Farzin, Raffaele Nuzzi, Marijana Basic, Silvia Bolsega, Stefano Geuna, Matilde Cescon, Kirsten Haastert-Talini, Kirsten Haastert-Talini, Giovanna Gambarotta   +13 more
doaj   +1 more source

Damage to the eye and optic nerve in seriously traumatized patients with concomitant head injury: analysis of 84,627 cases from the TraumaRegister DGU® between 2002 and 2015

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2020
Background To determine the prevalence and characteristics of prechiasmatic visual system injuries (VSI) among seriously injured patients with concomitant head trauma in Europe by means of a multinational trauma registry.
Torge Huckhagel, Jan Regelsberger, Manfred Westphal, Jakob Nüchtern, Rolf Lefering   +4 more
doaj   +1 more source

Near-complete optic nerve transection by high-pressure air [PDF]

Clinical and Experimental Emergency Medicine, 2016
The use of high-pressure air instruments has become more common. Consequently, there have been a number of cases of orbital emphysema caused by contact with high-pressure air.
Soo Won Ko, Jong Seok Lee, Han Sung Choi, Young Gwan Ko, Hoon Pyo Hong   +4 more
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Shared and Differential Retinal Responses against Optic Nerve Injury and Ocular Hypertension

Frontiers in Neuroscience, 2017
Glaucoma, one of the leading causes of blindness worldwide, affects primarily retinal ganglion cells (RGCs) and their axons. The pathophysiology of glaucoma is not fully understood, but it is currently believed that damage to RGC axons at the optic nerve
Manuel Vidal-Sanz, Caridad Galindo-Romero, Francisco J. Valiente-Soriano, Francisco M. Nadal-Nicolás, Arturo Ortin-Martinez, Giuseppe Rovere, Manuel Salinas-Navarro, Fernando Lucas-Ruiz, Maria C. Sanchez-Migallon, Paloma Sobrado-Calvo, Marcelino Aviles-Trigueros, María P. Villegas-Pérez, Marta Agudo-Barriuso   +12 more
doaj   +1 more source

The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve. [PDF]

PLoS ONE, 2013
Reactive gliosis is a complex process that involves changes in gene expression and morphological remodeling. The mouse optic nerve, where astrocytes, microglia and oligodendrocytes interact with retinal ganglion cell axons and each other, is a ...
Juan Qu, Tatjana C Jakobs
doaj   +1 more source

Mechanical Study on the Traumatic Optic Nerve Injury

Neurologia medico-chirurgica, 1971
Optic nerve injury or blindness after head trauma has well been known since the days of Hippocrates, and has still remained one of the serious posttaumatic sequelae. Statistically about 2% of head-injured persons suffer from the visual loss and are impelled to have limited social activites3).
HIRAKAWA, Kimiyoshi, HASHIZUME, Keizo, NAKAMURA, Norio, SANO, Keiji   +3 more
openaire   +3 more sources