Results 61 to 70 of about 1,469,459 (252)

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]

, 2012
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Yu, Alice L., Welge-Lussen, Ulrich, Moriniere, Jerome   +2 more
core   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Emergency management: optic nerve compression [PDF]

, 2018
Increased orbital pressure compresses the optic nerve, which can lead to irreversible vision loss in a matter of ...
Colin Cook
core  

Pediatric Traumatic Optic Neuropathy: A Case of Emergency Multidisciplinary Surgical Decompression

Archives of Pediatric Neurosurgery
Background: Traumatic optic neuropathy (TON) following orbital roof fractures is rare in pediatric populations but represents a surgical emergency due to risk of permanent blindness.
Déborah Laurindo Pereira Santos , Renato Torres Augusto Neto , Mário Francisco Real Gabrielli, Eduardo Hochuli Vieira   +3 more
doaj   +1 more source

Magnetic resonance imaging indicator of the causes of optic neuropathy in IgG4-related ophthalmic disease

BMC Medical Imaging, 2019
Background The following study investigates the involvement of optic neuropathy in IgG4-related ophthalmic diseases (IgG4-ROD) based on the magnetic resonance imaging (MRI) data, and different imaging features of IgG4-ROD related optic neuropathy related
Jing Li, Yan Zhang, Hang Zhou, Lei Wang, Zhenchang Wang, Hongyang Li   +5 more
doaj   +1 more source

Optic Nerve Crush Injury in Rodents to Study Retinal Ganglion Cell Neuroprotection and Regeneration

, 2023
Optic nerve crush injury is a useful model for studying the response of central nervous system neurons (CNS) to injury. A particular focus of this model has been to elucidate therapeutic factors in promoting neuroprotection and axon regeneration after ...
Ahmed, Zubair; id_orcid
core   +1 more source

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

Regos nervo sužalojimas: literatūros apžvalga

Lietuvos Chirurgija, 2011
Rūta Pukenytė1, Gytis Šustickas2, Jelena Ščerbak2, Darius Aukštikalnis1, Rimvydas Ašoklis1 1 Vilniaus universiteto Ausų, nosies, gerklės ir akių ligų klinika, Santariškių g.
Rūta Pukenytė, Gytis Šustickas, Jelena Ščerbak, Darius Aukštikalnis, Rimvydas Ašoklis   +4 more
doaj  

Our Experience in Endoscopic Transnasal Optic Nerve Decompression

Bengal Journal of Otolaryngology and Head Neck Surgery
INTRODUCTION: Traumatic optic neuropathy (TON), a severe complication following head injury, affects about 0.5% to 5% of patients with closed head injuries.1 Visual acuity (VA) loss associated with TON can be partial or complete and temporary or ...
Saravana Selvan Velmurugan , VIVEK Mariappan, Mohamed Siddique Samsudeen, SURESH KUMAR Narayanan, Asith Jakkiriya Basha, Revathi Subramanian   +5 more
doaj   +1 more source