Results 91 to 100 of about 584,777 (259)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Optic Nerve Avulsion and Retinal Detachment After Penetrating Ocular Trauma: Case Report

, 2018
Optic nerve avulsion is a rare pathology with poor prognosis usually seen after blunt trauma. The optic nerve is separated from the sclera by indirect forces due to the relatively weak structure of the lamina cribrosa area.
Mehmet Fatih Kağan Değirmenci, Hüban Atilla, Nilüfer Yalçındağ   +2 more
core   +1 more source

Postural changes in optic nerve and optic nerve sheath diameters in postural orthostatic tachycardia syndrome and spontaneous intracranial hypotension: A cohort study. [PDF]

, 2019
BACKGROUND Postural orthostatic tachycardia syndrome is a disorder of the autonomic nervous system. Approximately 30% of patients experience orthostatic headaches.
Werner J Z'Graggen, Belén Rodriguez (5338697), Raya Zimmermann (7480835), Fichtner, Jens, Andreas Raabe (289411), Werner J. Z‘Graggen (7480841), Jens Fichtner, Beck, Jürgen, Debora Cipriani (7480832), Belén Rodriguez, Levin Häni (2805976), Debora Cipriani, Raya Zimmermann, Raabe, Andreas, Cipriani, Debora, Z'Graggen, Werner J., Andreas Raabe, Ulrich, Christian T., Christian T. Ulrich (7480838), Christian T Ulrich, Z’Graggen, Werner Josef, Jürgen Beck (195467), Rodriguez, Belén, Zimmermann, Raya, Levin Häni, Häni, Levin, Jens Fichtner (795231), Jürgen Beck   +27 more
core   +2 more sources

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Bilateral Optic Nerve Enhancement in Posterior Ischemic Optic Neuropathy Secondary to Hypovolemic Shock

, 2021
Enhancement of the optic nerve is occasionally noted in patients with arteritic ischemic optic neuropathy (ION) and non-arteritic anterior ION. We report a rare case of bilateral optic nerve enhancement in hypotension-related posterior ION (PION)
Mehdi Tavakoli; Michael S. Vaphides, Mehdi Tavakoli; Michael Vaphiades   +1 more
core  

Optic nerve avulsion after blunt ocular trauma – Case report [PDF]

, 2016
Introduction Avulsion of the optic nerve head is a rare and severe complication of ocular blunt trauma. The case reported is a 28-year old man presenting to the emergency department due to blunt trauma to his right eye globe with a tree branch.
Monika Jasielska, Mackiewicz, J., Tomaszewska, J., Jasielska, M., Joanna Tomaszewska, Jerzy Mackiewicz   +5 more
core   +2 more sources

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Acute vision loss as the presenting symptom of metastatic prostate cancer: A case report and review of the literature

Otolaryngology Case Reports
Objective: Primary sphenoid sinus neoplasms are rare, and metastasis to this site is even more uncommon. While prostate cancer is the most frequently diagnosed malignancy in men, it rarely spreads to the paranasal sinuses.
Eugene Oh, Jessa E. Miller, Haidee Chen, D. Alexander Cronkite, Janice Chung, Jeffrey D. Suh, Isaac Yang, Jivianne T. Lee, Marilene B. Wang, Daniel M. Beswick   +9 more
doaj   +1 more source

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source