Results 71 to 80 of about 49,888 (287)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Unilateral Acute Anterior Ischemic Optic Neuropathy in a Patient with an Already Established Diagnosis of Bilateral Optic Disc Drusen

Case Reports in Ophthalmological Medicine, 2015
Optic disc drusen (ODD) are calcific deposits that form in the optic nerve head secondary to abnormalities in axonal metabolism and degeneration. Anterior ischemic optic neuropathy, central retinal artery, and vein occlusion are among the rare vascular ...
Ziya Ayhan, Aylin Yaman, Meltem Söylev Bajin, A. Osman Saatci   +3 more
doaj   +1 more source

Differential intensity contrast swept source optical coherence tomography for human retinal vasculature visualization [PDF]

, 2012
We demonstrate an intensity-based motion sensitive method, called differential logarithmic intensity variance (DLOGIV), for 3D microvasculature imaging and foveal avascular zone (FAZ) visualization in the in vivo human retina using swept source optical ...
Fraser, Scott, Motaghiannezam, Reza
core   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Valosin-containing protein modulator KUS121 protects retinal neurons in a rat model of anterior ischemic optic neuropathy

Scientific Reports
Ischemic optic neuropathy is a leading cause of sudden vision loss, particularly in elderly individuals, with no available effective treatments. Ischemia-induced irreversible damage to optic nerve fibers highlights the need for novel therapies with ...
Chinami Kikkawa, Hanako Ohashi Ikeda, Masayuki Hata, Sachiko Iwai, Akitaka Tsujikawa   +4 more
doaj   +1 more source

Arteritic Anterior Ischemic Optic Neuropathy (AAION) Associated with COVID-19 Infection: A Case Report and Review of the Literature

Case Reports in Ophthalmological Medicine, 2023
Anterior ischemic optic neuropathy (AION) is the most frequent cause of acute optic nerve damage in the elderly, usually causing acute, unilateral, and painless permanent visual loss.
Kourosh Shahraki, Amin Najafi, Negin Ashoori, Nayyereh Razzaghpour, Kianoush Shahraki   +4 more
doaj   +1 more source

Glaucomatous vertical vessel density asymmetry of the temporal raphe detected with optical coherence tomography angiography. [PDF]

, 2020
Changes in retinal vasculature and ocular circulation may play an important role in the glaucoma development and progression. We evaluated the vertical asymmetry across the temporal raphe of the deep retinal layer vessel density, using swept-source ...
Araie, Makoto, Ibuki, Hisashi, Kanno, Junji, Shinoda, Kei, Shoji, Takuhei, Weinreb, Robert N, Yoshikawa, Yuji   +6 more
core  

Obstructive sleep apnea and ocular disorders. [PDF]

, 2010
PURPOSE OF REVIEW: Obstructive sleep apnea is a diagnosis that ophthalmologists can screen for when a patient presents with certain risk factors. Recent literature provides strong data for associations between sleep apnea and ocular disorders.
Grover, Deepak P.
core   +2 more sources

Choroidal Vascular Changes in Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathy.

American journal of ophthalmology-glaucoma, 2019
PURPOSE To compare choroidal vascularity index (CVI) in patients with arteritic anterior ischemic optic neuropathy (A-AION), non-arteritic anterior ischemic optic neuropathy (NA-AION) and control subjects.
M. Pellegrini, G. Giannaccare, F. Bernabei, Fabiana Moscardelli, Costantino Schiavi, E. Campos   +5 more
semanticscholar   +1 more source

Long‐Term Quality of Life in 1777 Persons With Hodgkin Lymphoma and 6166 Matched Comparators

American Journal of Hematology, EarlyView.
ABSTRACT Survival has improved substantially for patients with Hodgkin lymphoma (HL), but long‐term quality of life (QoL) remains incompletely understood. This was a Danish, nationwide, cross‐sectional study of QoL among persons with a diagnosis of HL matched 1:10 to general population comparators.
Sissel Johanne Godtfredsen, Joachim Baech, Mikkel Porsborg Andersen, Harman Yonis, Paw Jensen, Peter Kamper, Jacob H. Christensen, Rasmus Bo‐Dahl Sørensen, Martin Hutchings, Christian Torp‐Pedersen, Peter Sogaard, Henrik Boggild, Kristian H. Kragholm, Tarec C. El‐Galaly   +13 more
wiley   +1 more source