Results 101 to 110 of about 1,383,877 (253)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

The hidden dangers: Delayed fatal apoplexy in adult-onset optic pathway glioma following biopsy

Interdisciplinary Neurosurgery
Background: Optic pathway gliomas (OPG) are the most common primary neoplasm of the optic pathway. They are most commonly seen in children less than 8 years of age. Adult onsets OPG are rare entity. Hemorrhage (Apoplexy) in these tumors is rare and it is
Dawit Workneh Gechu, Mehari Wale Alem, Abel Gizaw Woldegabriel, Yordanos Girma Legesse, Mieraf Bayouh Alemu, Peniel Zewdie Abera   +5 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

NF-Protocadherin Regulates Retinal Ganglion Cell Axon Behaviour in the Developing Visual System.

PLoS ONE, 2015
Cell adhesion molecules play a central role in mediating axonal tract development within the nascent nervous system. NF-protocadherin (NFPC), a member of the non-clustered protocadherin family, has been shown to regulate retinal ganglion cell (RGC) axon ...
Louis C Leung, William A Harris, Christine E Holt, Michael Piper   +3 more
doaj   +1 more source

Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway

Scientific Reports, 2020
Sproutys are negative regulators of the Ras/Raf/MAPK signaling pathway and involved in regulation of organogenesis, differentiation, cell migration and proliferation.
Jian Sun, Jaeho Yoon, Moonsup Lee, Yoo-Seok Hwang, Ira O. Daar   +4 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Binocular contributions to optic flow processing in the fly visual system [PDF]

, 2001
Krapp HG, Hengstenberg R, Egelhaaf M. Binocular contributions to optic flow processing in the fly visual system. Journal of neurophysiology. 2001;85(2):724-734.Integrating binocular motion information tunes wide-field direction-selective neurons in the ...
Hengstenberg, Roland, Egelhaaf, M., Holger G. Krapp, Hengstenberg, R., Egelhaaf, Martin ; https://orcid.org/, Martin Egelhaaf, Krapp, Holger G., Roland Hengstenberg, Krapp, H.   +8 more
core   +1 more source

SERF-MEG as a Functional Biomarker of Optic Nerve Injury: Agreement and Correlation with Visual Evoked Potentials

Bioengineering
This study assessed the cross-modal agreement between spin-exchange relaxation-free magnetoencephalography (SERF-MEG) and conventional visual evoked potentials (VEPs) in patients with optic nerve injury using comparable pattern-reversal visual ...
Helei Wang, Yuankun Qi, Yu Lou, Xu Zhang, Xinda Song   +4 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source