Results 81 to 90 of about 1,383,877 (253)

Age effect on retina and optic disc normal values [PDF]

, 2005
Purpose: To investigate retinal thickness and optic disc parameters by the Retinal Thickness Analyzer (RTA) glaucoma program in older normal subjects and to determine any age effect.
Chryssafis, C., Hirneiß, Christoph, Neubauer, A. S., Tsinopoulos, I., Kampik, Anselm, Thiel, M.   +5 more
core   +1 more source

Causal effect of COVID-19 on optic nerve and visual pathway disorders: genetic evidence of lung-brain axis

Frontiers in Immunology
PurposeTo investigate the potential causal association between COVID-19 exposure and optic nerve and visual pathway disorders through a two-sample bidirectional Mendelian randomization (MR) analysis, and to provide empirical support for the lung-brain ...
Chunge Cao, Qiong Li, Dajun Cai, Chaoyan Yue, Hu Zhao   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Connections of the corpus cerebelli in the green sunfish and the common goldfish [PDF]

, 1988
Examination of the connections of the corpus cerebelli in one perciform (Lepomis cyanellus) and one cypriniform teleost (Carassius auratus) reveal that ipsilateral afferent connections in both species arise from an anterior group of nuclei in the ...
Northcutt, R. Glenn, Wullimann, Mario F.
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Accurate and reliable segmentation of the optic disc in digital fundus images [PDF]

, 2014
We describe a complete pipeline for the detection and accurate automatic segmentation of the optic disc in digital fundus images. This procedure provides separation of vascular information and accurate inpainting of vessel-removed images, symmetry-based ...
Giachetti, Andrea, Emanuele Trucco, Trucco, Emanuele; id_orcid, Lucia Ballerini, Ballerini, Lucia   +4 more
core   +1 more source

CT perfusion parameters in visual pathway alterations in optic neuritis: four-case series

The Egyptian Journal of Radiology and Nuclear Medicine
Background Optic neuritis is primarily an inflammatory demyelinating disorder of the optic nerve; however, emerging evidence suggests that vascular hypoperfusion may also contribute to visual pathway involvement.
Firman Adi Prasetyo, Anggraini Dwi Sensusiati   +1 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Defining Meyer's loop-temporal lobe resections, visual field deficits and diffusion tensor tractography [PDF]

, 2009
Anterior temporal lobe resection is often complicated by superior quadrantic visual field deficits (VFDs). In some cases this can be severe enough to prohibit driving, even if a patient is free of seizures.
M Yogarajah (16050209), J S Duncan (16050227), McEvoy, A.W., M J Koepp (13602235), Focke, N.K., Koepp, M. J., Duncan, John S., M R Symms (16042382), Koepp, Matthias J., Duncan, J.S., Symms, M.R., Alexander, D. C., Parker, G. J M, Acheson, J., Bonelli, S., A W McEvoy (16050224), S Bonelli (16050215), G J M Parker (16050218), Mara Cercignani (4463104), Alexander, Daniel C., Alexander, D.C., Koepp, M.J., McEvoy, A. W., Parker, G.J.M., J Acheson (10343627), Yogarajah, Mahinda, Symms, Mark R., Bonelli, Silvia B., Cercignani, M., D C Alexander (16050221), Yogarajah, M., Focke, N. K., Symms, M. R., Focke, Niels K., Duncan, J. S., N K Focke (16050212), Parker, G. J. M.   +36 more
core   +1 more source