Results 71 to 80 of about 1,383,877 (253)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Cupped disc with normal intraocular pressure: The long road to avoid misdiagnosis
Indian Journal of Ophthalmology, 2011 We present a series of six patients who had been receiving treatment for normal tension glaucoma (NTG; five patients) or primary open angle glaucoma (one patient).
Nikhil S Choudhari +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Optic disc Pit with Retinoschisis in Non-Arteritic Anterior Ischemic Optic Neuropathy
, 2023 This case describes a patient with non-arteritic anterior ischemic optic neuropathy and concurrent macular retinoschisis who was later found to have an optic disc pit after resolution of disc edema.
Abraham Hang, MD; Megan M Hughes-Salabar, COA; Yin Allison Liu, MD, PhD
core
Macrocephaly in neurofibromatosis type 1: a sign post for optic pathway gliomas? [PDF]
, 2011 Optic pathway gliomas, which occur in 15-20% of paediatric patients with neurofibromatosis type 1, are the most common central nervous system tumour associated with this neurocutaneous disorder.
Barbara Goeggel Simonetti +13 more
core +2 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
, 2023 Optic pathway enlargement (OPE) has recently been associated with morning glory disc anomaly (MGDA), though the literature is limited.[1,2] Herein, we report, to our knowledge, the case series of patients of MGDA associated with OPE that details both ...
Paul H. Phillips; Alexander Kwok; Raghuhr Ramakrishnaiah; Abdelrahman Elhusseiny
core
Assessment of stereoscopic optic disc images using an autostereoscopic screen - experimental study [PDF]
, 2008 BACKGROUND: Stereoscopic assessment of the optic disc morphology is an important part of the care of patients with glaucoma. The aim of this study was to assess stereoviewing of stereoscopic optic disc images using an example of the new technology of ...
Habib, M.S. +20 more
core +2 more sources
Optic Pathway Tumors and Precocious Puberty
Pediatric Neurology Briefs, 1995 The prevalence of precocious puberty and its relationship to optic pathway tumors (OPTs) have been examined in 219 children with neurofibromatosis 1 (NF-1) seen between Jan 1985 and April 1993 at Children’s Memorial Hospital, Chicago.
J Gordon Millichap
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source