Results 101 to 110 of about 3,058,814 (268)

Packet-Layer Forward Error Correction Coding for Fading Mitigation

, 2006
In an on/off-keying atmospheric optical communication system, index of refraction turbulence and PAT (pointing, acquisition and tracking) instabilities create strong and very slow fading compared to the usually used high data-rates.
Hennes Henniger, Henniger, Hennes
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Applications of polymer optical fibre grating sensors to condition monitoring of textiles [PDF]

, 2009
Fibre Bragg gratings (FBGs) in polymer optical fibres (POFs) have been used to measure the strain in a woven textile. FBGs in both POFs and silica optical fibres were attached to a woven textile specimen, and their performance characterised.
Ye, Chen Chun, Dulleu-Barton, J. M., Chambers, A. R., Lennard, F. J., D. D. Eastop, Zhang, Chi, Peng, Gang-Ding, A. R. Chambers, Eastop, D.D., Dulieu-Barton, Janice M., 叶陈春, D. J. Webb, Webb, D. J., F. J. Lennard, C. C. Ye, Ye, C.C., Chambers, A.R., G.-D. Peng, Zhang, C., Lennard, F.J., Webb, D.J., Peng, G.-D., J. M. Dulieu-Barton, Ye, C. C., Eastop, D. D., C. Zhang, Webb, David J., Peng, G. D., Peng, G.D, Dulieu-Barton, J.M.   +29 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Evaluation of the Scintillation Loss for Optical Communication Systems with Direct Detection

, 2006
In optical communications through the atmosphere, the evaluation of a link feasibility often requires the quantification of the scintillation penalty in terms of power loss. To find how much additional optical power is needed to reach the bit-error-rate (
Perlot, Nicolas
core  

A multiplexed CW Brillouin system for precise interrogation of a sensor array made from short discrete sections of optical fibre [PDF]

, 2008
A novel configuration for precise temperature sensing in an array of optical fibre sections is reported. The sections are chosen to have different Brillouin shifts, to enable separation of scattered light signals in the frequency domain, rather than the ...
Dakin, J. P., Thévenaz, Luc, Thévenaz, L., J. P. Dakin, L. Thévenaz, Dakin, J.P., S. Chin, Chin, S.   +7 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Integrated optical sensor system for beverage analysis

, 1998
Integrated optical transducers for the detection of chemical and biochemical species and for optical measurements on bulk media are the subject of intense research effort. While many such sensors have been demonstrated in research laboratories worldwide,
Luff, B.J., K. Kawaguchi, B. J. Luff, James S. Wilkinson, Kawaguchi, K., Wilkinson, J.S.   +5 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source