Results 101 to 110 of about 3,501,692 (262)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Surface imaging of metallic material fractures using optical coherence tomography [PDF]

, 2014
We demonstrate the capability of optical coherence tomography (OCT) to perform topography of metallic surfaces after being subjected to ductile or brittle fracturing.
Demian, D., Hutiu, G., Bradu, Adrian, Podoleanu, Adrian G.H., Duma, V.F.   +4 more
core   +1 more source

Application of Optical Remote Sensing in Harmful Algal Blooms in Lakes: A Review

Remote Sensing
Harmful algal blooms (HABs) are a critical global issue, severely impacting aquatic ecosystems, public health, and economies. Optical remote sensing (ORS) has emerged as a prominent tool for HABs monitoring, providing operational capabilities for ...
Simeng Wang, Boqiang Qin
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Fixed-rate-breaking All-optical OFDM system using time-domain hybrid PAM with sparse subcarrier multiplexing and power-loading for optical short-reach transmission

, 2020
All-optical TDHP-OFDM system with four-sparse-subcarrier-multiplexing and power-loading has been proposed for data-rate-adaptive transmission. 40-Gbit/s, 60-Gbit/s, and 80-Gbit/s can be selected by changing the ratio of PAM2 and PAM4, and all BERs ...
Kodama T., Wada N., Cincotti G., Maruta A.   +3 more
core   +1 more source

Evaluation of FEC for the atmospheric optical IM/DD channel [PDF]

, 2003
Channel measurements were performed by the German Aerospace Center in various near ground optical channels including a 1.5 km horizontal path as well as a 61km path.
Hennes Henniger, Giggenbach, Dirk, Henniger, Hennes, Christoph Rapp, Florian David, David, Florian, Rapp, Christoph, Dirk Giggenbach   +7 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Assimilating Soil Moisture Retrieved from Sentinel-1 and Sentinel-2 Data into WOFOST Model to Improve Winter Wheat Yield Estimation

Remote Sensing, 2019
Crop yield estimation at a regional scale over a long period of time is of great significance to food security. In past decades, the integration of remote sensing observations and crop growth models has been recognized as a promising approach for crop ...
Wen Zhuo, Jianxi Huang, Li Li, Xiaodong Zhang, Hongyuan Ma, Xinran Gao, Hai Huang, Baodong Xu, Xiangming Xiao   +8 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Optical Extinction Ratio Monitoring Techniques Using Optical Spectrum Analysis

, 2011
An optical extinction ratio monitoring technique for wavelength-division-multiplexed passive optical network systems is proposed. This technique is based on the optical spectrum analysis.
Yang, Chun-Liang
core   +1 more source