Results 111 to 120 of about 3,058,814 (268)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Precision dicing of optical materials [PDF]

, 2014
Ductile regime dicing has been used to machine a variety of optical materials to produce waveguides for lasers, multi-mode interference devices and non-linear devices.
Smith, P.G.R., Carpenter, Lewis, Cooper, P.A., J. C. Gates, P. A. Cooper, Holmes, C., C. Holmes, Gates, J.C., L. G. Carpenter, P. G. R. Smith   +9 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Optical Extinction Ratio Monitoring Techniques Using Optical Spectrum Analysis

, 2011
An optical extinction ratio monitoring technique for wavelength-division-multiplexed passive optical network systems is proposed. This technique is based on the optical spectrum analysis.
Yang, Chun-Liang
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Evaluation of FEC for the atmospheric optical IM/DD channel

, 2003
Channel measurements were performed by the German Aerospace Center in various near ground optical channels including a 1.5 km horizontal path as well as a 61km path.
Hennes Henniger, Giggenbach, Dirk, Henniger, Hennes, Christoph Rapp, Florian David, David, Florian, Rapp, Christoph, Dirk Giggenbach   +7 more
core   +1 more source

Asymmetric optical loop mirror : analysis of an all-optical switch [PDF]

, 1994
A general analytical framework for tetrahertz optical asymmetric demultiplexer (TOAD) switch operation is presented and compared with other switches that use a nonlinear optical element in a loop mirror.
Glesk, Ivan, Prucnal, Paul R., Kane, Michael G., Sokoloff, Jason P.   +3 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Green-pumped, picosecond MgO:PPLN optical parametric oscillator

, 2011
We investigate the performance of a magnesium-oxide-doped periodically poled lithium niobate crystal (MgO:PPLN) in an optical parametric oscillator (OPO) synchronously-pumped by 530nm, 20ps, 230MHz pulses with an average power of up to 2W from a ...
Florian Kienle, Dejiao Lin, Lin, Dejiao, David J. Richardson, Major, Huw, Richardson, David J., Kienle, Florian, Shepherd, David P., Shaif-ul Alam, Gawith, Corin B.E., Corin B. E. Gawith, Hung, Hazel, Huw E. Major, Alam, Shaif-ul, David P. Shepherd, Hazel S. S. Hung   +15 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source