Results 91 to 100 of about 1,579,823 (328)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Implementation of FORMIDABLE: A generalized differential optical design library with NURBS capabilities

open access: yesJournal of the European Optical Society-Rapid Publications
In this article we describe the implementation of Freeform Optics Raytracer with Manufacturable Imaging Design cApaBiLitiEs (FORMIDABLE): an optical design library capable of simulating optical systems by ray-tracing.
Volatier Jean-Baptiste   +4 more
doaj   +1 more source

Design and Characterization of Low-Loss Porous-Core Photonic Crystal Fiber

open access: yesIEEE Photonics Journal, 2012
A rigorous modal solution approach, based on the numerically efficient finite-element method (FEM), has been used to design and characterize a photonic crystal fiber (PCF) with a porous air core, which has the potential for use for low-loss guidance of ...
M. Uthman   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

A Study of High-Efficiency Laser Headlight Design Using Gradient-Index Lens and Liquid Lens

open access: yesApplied Sciences, 2020
In the field of vehicle lighting, due to the diode laser, its small size and high energy conversion efficiency, it can be effectively used as the headlight source of high beam.
Yi-Chin Fang   +6 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Development and Application of Unmanned Aerial High-Resolution Convex Grating Dispersion Hyperspectral Imager

open access: yesSensors
This study presents the design and development of a high-resolution convex grating dispersion hyperspectral imaging system tailored for unmanned aerial vehicle (UAV) remote sensing applications.
Qingsheng Xue   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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