Results 11 to 20 of about 37,830 (248)
Optical map guided genome assembly [PDF]
BMC Bioinformatics, 2020 Background The long reads produced by third generation sequencing technologies have significantly boosted the results of genome assembly but still, genome-wide assemblies solely based on read data cannot be produced.
Miika Leinonen, Leena Salmela
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Validation of rice genome sequence by optical mapping [PDF]
BMC Genomics, 2007 Background Rice feeds much of the world, and possesses the simplest genome analyzed to date within the grass family, making it an economically relevant model system for other cereal crops. Although the rice genome is sequenced, validation and gap closing
Pape Louise +10 more
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Rapid whole genome optical mapping of
Malaria Journal, 2011 Background Immune evasion and drug resistance in malaria have been linked to chromosomal recombination and gene copy number variation (CNV). These events are ideally studied using comparative genomic analyses; however in malaria these analyses are not as
Johnson Jake D +4 more
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Optical mapping of the
BMC Genomics, 2009 Background Infection of cattle with Mycobacterium avium subspecies paratuberculosis (M. ap) causes severe economic losses to the dairy industry in the USA and worldwide. In an effort to better examine diversity among M.
Schwartz David C +4 more
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Optical genome mapping identified deletions, inversions, and insertions in hemophilia. [PDF]
Blood AdvLiu B +9 more
europepmc +4 more sources
Unveiling genomic rearrangements in engineered iPSC lines by optical genome mapping. [PDF]
Mol Ther Methods Clin DevABSTRACT We demonstrate here the use of optical genome mapping (OGM) to detect genetic alterations arising from gene editing by various technologies in human induced pluripotent stem cells (iPSCs). OGM enables an unbiased and comprehensive analysis of the entire genome, allowing the detection of genomic structural variants (SVs) of all ...
Finlay D +6 more
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Optical mapping in plant comparative genomics [PDF]
GigaScience, 2015 Optical mapping has been widely used to improve de novo plant genome assemblies, including rice, maize, Medicago, Amborella, tomato and wheat, with more genomes in the pipeline. Optical mapping provides long-range information of the genome and can more easily identify large structural variations.
Tang, Haibao +2 more
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Multiplex structural variant detection by whole-genome mapping and nanopore sequencing
Scientific Reports, 2022 Identification of structural variants (SVs) breakpoints is important in studying mutations, mutagenic causes, and functional impacts. Next-generation sequencing and whole-genome optical mapping are extensively used in SV discovery and characterization ...
Lahari Uppuluri +5 more
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OMGS: Optical Map-based Genome Scaffolding [PDF]
Journal of Computational Biology, 2019 Abstract Due to the current limitations of sequencing technologies, de novo genome assembly is typically carried out in two stages, namely contig (sequence) assembly and scaffolding.
Weihua Pan +2 more
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A Gene-Based Method for Cytogenetic Mapping of Repeat-Rich Mosquito Genomes
Insects, 2021 Long-read sequencing technologies have opened up new avenues of research on the mosquito genome biology, enabling scientists to better understand the remarkable abilities of vectors for transmitting pathogens.
Reem A. Masri +3 more
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