Results 11 to 20 of about 99,235 (279)
Advances in optical mapping for genomic research
Computational and Structural Biotechnology Journal, 2020 Recent advances in optical mapping have allowed the construction of improved genome assemblies with greater contiguity. Optical mapping also enables genome comparison and identification of large-scale structural variations.
Yuxuan Yuan +2 more
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Optical map guided genome assembly [PDF]
BMC Bioinformatics, 2020 Background The long reads produced by third generation sequencing technologies have significantly boosted the results of genome assembly but still, genome-wide assemblies solely based on read data cannot be produced.
Miika Leinonen, Leena Salmela
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Sequencing and Optical Genome Mapping for the Adventurous Chemist [PDF]
Chemical & Biomedical ImagingThis review provides a comprehensive overview of the chemistries and workflows of the sequencing methods that have been or are currently commercially available, providing a very brief historical introduction to each method. The main optical genome mapping approaches are introduced in the same manner, although only a subset of these are or have ever ...
Elizabete Ruppeka Rupeika +3 more
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Validation of rice genome sequence by optical mapping [PDF]
BMC Genomics, 2007 Background Rice feeds much of the world, and possesses the simplest genome analyzed to date within the grass family, making it an economically relevant model system for other cereal crops. Although the rice genome is sequenced, validation and gap closing
Pape Louise +10 more
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Optical mapping of the
BMC Genomics, 2009 Background Infection of cattle with Mycobacterium avium subspecies paratuberculosis (M. ap) causes severe economic losses to the dairy industry in the USA and worldwide. In an effort to better examine diversity among M.
Schwartz David C +4 more
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Optical genome mapping identified deletions, inversions, and insertions in hemophilia [PDF]
Blood AdvancesBoyan Liu +9 more
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Optical mapping in plant comparative genomics [PDF]
GigaScience, 2015 Optical mapping has been widely used to improve de novo plant genome assemblies, including rice, maize, Medicago, Amborella, tomato and wheat, with more genomes in the pipeline. Optical mapping provides long-range information of the genome and can more easily identify large structural variations.
Tang, Haibao +2 more
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Optical Whole-Genome Restriction Mapping as a Tool for Rapidly Distinguishing and Identifying Bacterial Contaminants in Clinical Samples [PDF]
Journal of Clinical and Diagnostic Research, 2015 Introduction: Optical restriction genome mapping is a technology in which a genome is linearized on a surface and digested with specific restriction enzymes, giving an arrangement of the genome with gaps whose order and size are unique for a given ...
Richard R. Chapleau, James C. Baldwin
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Multiplex structural variant detection by whole-genome mapping and nanopore sequencing
Scientific Reports, 2022 Identification of structural variants (SVs) breakpoints is important in studying mutations, mutagenic causes, and functional impacts. Next-generation sequencing and whole-genome optical mapping are extensively used in SV discovery and characterization ...
Lahari Uppuluri +5 more
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Optical Genome Mapping: A New Tool for Cytogenomic Analysis. [PDF]
Genes (Basel)Background/Objectives: Optical genome mapping (OGM) has recently emerged as a new technology in the clinical cytogenomics laboratories. This methodology has the ability to detect balanced and unbalanced structural rearrangements using ultra-high molecular weight DNA.
Levy B, Burnside RD, Akkari Y.
europepmc +3 more sources