Results 41 to 50 of about 38,693 (276)

Computational methods for optical mapping [PDF]

, 2014
Optical mapping and newer genome mapping technologies based on nicking enzymes provide low resolution but long-range genomic information. The optical mapping technique has been successfully used for assessing the quality of genome assemblies and for ...
Lee Mendelowitz, Pop, Mihai, Mihai Pop, Mendelowitz, Lee   +3 more
core   +1 more source

nanotatoR: a tool for enhanced annotation of genomic structural variants

BMC Genomics, 2021
Background Whole genome sequencing is effective at identification of small variants, but because it is based on short reads, assessment of structural variants (SVs) is limited. The advent of Optical Genome Mapping (OGM), which utilizes long fluorescently
Surajit Bhattacharya, Hayk Barseghyan, Emmanuèle C. Délot, Eric Vilain   +3 more
doaj   +1 more source

Optikai genomtérképezés onkohematológiai megbetegedésekben = Optical genome mapping in hematological malignancies [PDF]

, 2023
A hematológiai malignitások diagnosztikájában mai napig meghatározó szerepet tölt be a hagyományos kariotipizálás és a fluoreszcens in situ hibridizáció.
Donát Alpár, Bekő, Anna, Csaba Bödör, Bödör, Csaba, Anna Bekő, Alpár, Donát   +5 more
core   +1 more source

Is It Ordered Correctly? Validating Genome Assemblies by Optical Mapping [PDF]

The Plant Cell, 2017
Long-read single-molecule sequencing, Hi-C sequencing, and improved bioinformatic tools are ushering in an era where complete genome assembly will become common for species with few or no classical genetic resources. There are no guidelines for how to proceed in such cases.
Joshua A. Udall, R. Kelly Dawe
openaire   +2 more sources

Large Chromosomal Rearrangements during a Long-Term Evolution Experiment with Escherichia coli

mBio, 2014
Large-scale rearrangements may be important in evolution because they can alter chromosome organization and gene expression in ways not possible through point mutations.
Colin Raeside, Joël Gaffé, Daniel E. Deatherage, Olivier Tenaillon, Adam M. Briska, Ryan N. Ptashkin, Stéphane Cruveiller, Claudine Médigue, Richard E. Lenski, Jeffrey E. Barrick, Dominique Schneider   +10 more
doaj   +1 more source

Optical Genome Mapping: A Promising New Tool to Assess Genomic Complexity in Chronic Lymphocytic Leukemia (CLL) [PDF]

, 2022
SIMPLE SUMMARY: Genome complexity, detected by chromosome banding analysis or chromosomal microarray analysis, is a poor prognostic factor for chronic lymphocytic leukemia (CLL).
Carme Melero, Collado, Rosa, Joanna Kamaso, de la Rosa, Mireia, Campoy, Silvia Ramos, Alonso, Sara, Hoischen, Alexander, Bougeon, Sandrine, Xavier Calvo, Calvo, Xavier, Ramos-Campoy, Silvia, Leonor Arenillas, Anna Puiggros, Marco Antonio Moro-García, García-Serra, Rocío, Alexander Hoischen, Puiggros, Anna, Gimeno, Eva, Marta Salido, Eva Gimeno, Salido, Marta, Rosa Collado, María Rodríguez-Rivera, Mantere, Tuomo, Schoumans, Jacqueline, Blanca Espinet, Ana Ferrer, Sandrine Bougeon, María, García-Malo, María Dolores, Arenillas, Leonor, Ferrer, Ana, Espinet, Blanca, Melero, Carme, Rocío García-Serra, Sara Alonso, María Dolores García-Malo, Rodríguez-Rivera, María, Tuomo Mantere, Moro-García, Marco Antonio, Mireia de la Rosa, Sandrine Bougeon, Silvia Ramos-Campoy, Jacqueline Schoumans, Kamaso, Joanna   +43 more
core   +1 more source

Analysis of Brachypodium genomes with genome-wide optical maps

Genome, 2018
Brachypodium distachyon (n = 5) is a diploid and has been widely used as a genetic model. Brachypodium stacei (n = 10) and B. hybridum (n = 15) are species that are related to B. distachyon, leading to an hypothesis that they are part of a polyploid series based on x = 5. Several lines of evidence suggest that this hypothesis is incorrect and that the
Zhu, Tingting, Hu, Zhaorong, Rodriguez, Juan C., Deal, Karin R., Dvorak, Jan, Vogel, John P, Liu, Zhiyong, Luo, Ming-Cheng   +7 more
openaire   +3 more sources

Proof of principle for shotgun DNA mapping by unzipping

, 2009
Ability to map polymerases and nucleosomes on chromatin is important for understanding the impact of chromatin remodeling on key cellular processes. Current methods (such as ChIP and ChIP-chip) have produced a wealth of information that demonstrates ...
Steven J. Koch, Herskowitz, Lawrence J., Steven Koch, Linh Le, Salvagno, Anthony L., Anthony L. Salvagno, R. Andy Maloney, Le, Linh, Linh N. Le, Lawrence J. Herskowitz, Anthony Salvagno, Koch, Steven J., Lawrence Herskowitz   +12 more
core   +1 more source

Optical genome mapping reveals and characterizes recurrent aberrations and new fusion genes in adult ALL

, 2022
Optical genome mapping results files on single patient level: SV (Structural Variants) CNV (Copy number Variants) Aneuploidies OGM raw data sets a are available from the corresponding author upon ...
Vangala, Deepak Ben, Nguyen, Huu Phuc, Vieler, Lisa-Marie, Nilius-Eliliwi, Verena, Gerding, Wanda Maria, Schroers, Roland   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source