Results 201 to 210 of about 37,830 (248)

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Optical genome mapping reveals novel structural variations in an autism spectrum disorder cohort. [PDF]

Comput Struct Biotechnol J
Zhang Y, Chien WT, Chan JY, Cheung TY, He Z, Yip KH, Chan DF, Chong JS, Waye MM, Chair SY, Chan TF.   +10 more
europepmc   +1 more source

Resolving complex genomic variation with optical mapping

South African Journal of Botany, 2017
openaire   +1 more source

Rare case of PLAG1::RUNX1 fusion mimicking classical t(8;21): the value of optical genome mapping in acute myeloid leukemia. [PDF]

Mol Cytogenet
Assaf N, Alawieh S, Hammoud R, Daudignon A, Luquet I, Lambert J, Terré C.   +6 more
europepmc   +1 more source

Optical genome mapping identifies rare structural variants in neural tube defects. [PDF]

Genome Res
Sahajpal NS, Dean J, Hilton B, Fee T, Skinner C, Hastie A, DuPont BR, Chaubey A, Friez MJ, Stevenson RE.   +9 more
europepmc   +1 more source

The Use of Optical Genome Mapping for the Detection of Tyrosine Kinase Gene Fusions in Myeloid/Lymphoid Neoplasms. [PDF]

J Cell Mol Med
Vanhevel J, Rack K, Ameye G, Mokrani H, De Bie J, Michaux L, Dewaele B.   +6 more
europepmc   +1 more source

Exploration of Neurodegenerative Diseases Using Long-Read Sequencing and Optical Genome Mapping Technologies. [PDF]

Mov Disord
Cogan G, Daida K, Blauwendraat C, Billingsley K, Brice A.   +4 more
europepmc   +1 more source

Elucidating the pathogenic mechanism of a pedigree with complex rearrangements on chromosome 4 using optical genome mapping technology: a study on the genetics and functional pathways in a child with developmental delay. [PDF]

Mol Cytogenet
Qin J, Zeng Y, Qin S, Wang W, Huang J, Wei X, Chang R, Zheng X, Li Y, Yuan D, Wei X.   +10 more
europepmc   +1 more source

Optical Genome Mapping for Cytogenetic Diagnostics in AML

Cancers, 2023
The classification and risk stratification of acute myeloid leukemia (AML) is based on reliable genetic diagnostics. A broad and expanding variety of relevant aberrations are structural variants beyond single-nucleotide variants. Optical Genome Mapping is an unbiased, genome-wide, amplification-free method for the detection of structural variants.
Huu Phuc Nguyen, Wanda Maria Gerding, Deepak Vangala   +2 more
exaly   +3 more sources

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Optical Genome Mapping for Oncology Applications

Current Protocols, 2023
AbstractOptical genome mapping (OGM) is a next‐generation cytogenomic technology that has the potential to replace standard‐of‐care technologies used in the genetic workup of various malignancies. The ability to detect various classes of structural variations that include copy number variations, deletions, duplications, balanced and unbalanced events ...
Nikhil Shri, Sahajpal, Ashis K, Mondal, Alex, Hastie, Alka, Chaubey, Ravindra, Kolhe   +4 more
openaire   +2 more sources