Results 211 to 220 of about 37,830 (248)

WHOLE GENOME OPTICAL MAPPING [PDF]

Proceedings of the 4th Asia-Pacific Bioinformatics Conference, 2005
An innovative new technology, optical mapping, is used to infer the genome map of the location of short sequence patterns called restriction sites. The technology, developed by David Schwartz, allows the visualization of the maps of randomly located single molecules around a million base pairs in length.
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Genomics via Optical Mapping II: Ordered Restriction Maps

Journal of Computational Biology, 1997
In this paper, we describe our algorithmic approach to constructing ordered restriction maps based on the data created from the images of population of individual DNA molecules (clones) digested by restriction enzymes. The goal is to devise map-making algorithms capable of producing high-resolution, high-accuracy maps rapidly and in a scalable manner ...
Thomas S. Anantharaman, Bud Mishra, David C. Schwartz   +2 more
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Optical genome mapping for prenatal diagnosis: A prospective study

Clinica Chimica Acta, 2023
Cytogenetic analysis provides important information for prenatal decision-making and genetic counseling. Optical genome mapping (OGM) has demonstrated its performances in retrospective studies. In our prospective study, we assessed the quality of DNA obtained from cultures of amniotic fluid (AF) and chorionic villi (CV) and evaluated the ability of OGM
Goumy, Carole, Guy Ouedraogo, Zangbéwendé, Soler, Gwendoline, Eymard-Pierre, Eleonore, Laurichesse, Hélène, Delabaere, Amélie, Gallot, Denis, Bouchet, Pamela, Perthus, Isabelle, Pebrel-Richard, Céline, Gouas, Laetitia, Salaun, Gaëlle, Salse, Jérôme, Véronèse, Lauren, Tchirkov, Andrei   +14 more
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Testing for Facioscapulohumeral Muscular Dystrophy with Optical Genome Mapping

Current Protocols, 2023
AbstractThe introduction of optical genome mapping has improved time constraints and a lack of specificity from previous methodologies when performing genome‐wide analyses of samples. Optical genome mapping allows for the detection of structural variations, aberrations, and functionality traits from a single stained molecule of DNA.
Pratik, Koppikar, Suresh, Shenoy, Naga, Guruju, Madhuri, Hegde   +3 more
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Optical Nano-mapping and Analysis of Plant Genomes

2016
Application of optical mapping based on BioNano Genomics Irys(®) technology ( http://www.bionanogenomics.com/ ) is growing rapidly since its debut in November 2012. The technology can be used to facilitate genome sequence assembly and analysis of genome structural variations.
Ming-Cheng, Luo, Karin R, Deal, Armond, Murray, Tingting, Zhu, Alex R, Hastie, Will, Stedman, Henry, Sadowski, Michael, Saghbini   +7 more
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Optical mapping of DNA: Single‐molecule‐based methods for mapping genomes

Biopolymers, 2011
AbstractThe technologies associated with DNA sequencing are rapidly evolving. Indeed, single‐molecule DNA sequencing strategies are cheaper and faster than ever before. Despite this progress, every sequencing platform to date relies on reading the genome in small, abstract fragments, typically of less than 1000 bases in length.
Robert K, Neely, Jochem, Deen, Johan, Hofkens   +2 more
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Optical PCR: Genomic analysis by long-range PCR and optical mapping

Mammalian Genome, 1999
Optical mapping is an approach for the rapid, automated, non-electrophoretic construction of ordered restriction maps of DNA from ensembles of single molecules. Previously, we used optical mapping to make high-resolution maps of large insert clones such as bacterial artificial chromosomes (BAC) and large genomic DNA molecules.
J, Skiadas, C, Aston, A, Samad, T S, Anantharaman, B, Mishra, D C, Schwartz   +5 more
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A shotgun optical map of the entire Plasmodium falciparum genome

Nature Genetics, 1999
The unicellular parasite Plasmodium falciparum is the cause of human malaria, resulting in 1.7-2.5 million deaths each year. To develop new means to treat or prevent malaria, the Malaria Genome Consortium was formed to sequence and annotate the entire 24.6-Mb genome.
Z, Lai, J, Jing, C, Aston, V, Clarke, J, Apodaca, E T, Dimalanta, D J, Carucci, M J, Gardner, B, Mishra, T S, Anantharaman, S, Paxia, S L, Hoffman, J, Craig Venter, E J, Huff, D C, Schwartz   +14 more
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Identification and Characterization of Chromothripsis by Optical Genome Mapping

Optical genome mapping (OGM) is a robust method for identifying and characterizing chromothripsis. While conventional short-read sequencing techniques encounter challenges in detecting chromothripsis due to limitations in read length and difficulties in analyzing repetitive sequences, OGM leverages the visualization of long DNA molecules to overcome ...
Pascal, Chambon, Mathilde, Quibeuf, Anne Marie, Guerrot   +2 more
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Genomics via optical mapping. III: Contiging genomic DNA.

Proceedings. International Conference on Intelligent Systems for Molecular Biology, 2000
In this paper, we describe our algorithmic approach to constructing an alignment of (contiging) a set of restriction maps created from the images of individual genomic (uncloned) DNA molecules digested by restriction enzymes. Generally, these DNA segments are sized in the range of 1-4 Mb.
Thomas S. Anantharaman, Bud Mishra, David C. Schwartz   +2 more
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