Results 11 to 20 of about 576,432 (292)

A comprehensive framework for evaluation of high pacing frequency and arrhythmic optical mapping signals [PDF]

Frontiers in Physiology, 2023
Introduction: High pacing frequency or irregular activity due to arrhythmia produces complex optical mapping signals and challenges for processing.
Girish S. Ramlugun, Girish S. Ramlugun, Kanchan Kulkarni, Kanchan Kulkarni, Nestor Pallares-Lupon, Nestor Pallares-Lupon, Bastiaan J. Boukens, Bastiaan J. Boukens, Igor R. Efimov, Igor R. Efimov, Igor R. Efimov, Edward J. Vigmond, Edward J. Vigmond, Olivier Bernus, Olivier Bernus, Richard D. Walton, Richard D. Walton   +16 more
doaj   +2 more sources

Optical mapping of contracting hearts. [PDF]

J Physiol, 2023
AbstractOptical mapping is a widely used tool to record and visualize the electrophysiological properties in a variety of myocardial preparations such as Langendorff‐perfused isolated hearts, coronary‐perfused wedge preparations, and cell culture monolayers.
Kappadan V, Sohi A, Parlitz U, Luther S, Uzelac I, Fenton F, Peters NS, Christoph J, Ng FS.   +8 more
europepmc   +8 more sources

A fully-automated low-cost cardiac monolayer optical mapping robot [PDF]

Frontiers in Cardiovascular Medicine, 2023
Scalable and high-throughput electrophysiological measurement systems are necessary to accelerate the elucidation of cardiac diseases in drug development.
Peter Lee, Peter Lee, Luqia Hou, Faisal J. Alibhai, Rasha Al-attar, Ana Simón-Chica, Andrés Redondo-Rodríguez, Yilin Nie, Maria Mirotsou, Michael A. Laflamme, Michael A. Laflamme, Michael A. Laflamme, Gayathri Swaminath, David Filgueiras-Rama, David Filgueiras-Rama, David Filgueiras-Rama   +15 more
doaj   +2 more sources

Spatial Autocorrelation of Martian Surface Temperature and Its Spatio-Temporal Relationships with Near-Surface Environmental Factors across China’s Tianwen-1 Landing Zone

Remote Sensing, 2021
Variations in the Martian surface temperature indicate patterns of surface energy exchange. The Martian surface temperature at a location is similar to those in adjacent locations; but, an understanding of temperature clusters in multiple locations will ...
Yaowen Luo, Jianguo Yan, Fei Li, Bo Li
doaj   +1 more source

Panoramic Endocardial Optical Mapping Demonstrates Serial Rotors Acceleration and Increasing Complexity of Activity During Onset of Cholinergic Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Activation during onset of atrial fibrillation is poorly understood. We aimed at developing a panoramic optical mapping system for the atria and test the hypothesis that sequential rotors underlie acceleration of atrial fibrillation during ...
Óscar Salvador‐Montañés, Rafael J. Ramirez, Yoshio Takemoto, Steven R. Ennis, Daniel Garcia‐Iglesias, Sicong Wang, Patrick J. Wolfer, Jiang Jiang, Sergey V. Mironov, Sandeep V. Pandit, José Jalife, Omer Berenfeld   +11 more
doaj   +1 more source

Structural Refinement by Direct Mapping Reveals Assembly Inconsistencies near Hi-C Junctions

Plants, 2023
High-throughput chromosome conformation capture (Hi-C) is widely used for scaffolding in de novo assembly because it produces highly contiguous genomes, but its indirect statistical approach can introduce connection errors.
Luca Marcolungo, Leonardo Vincenzi, Matteo Ballottari, Michela Cecchin, Emanuela Cosentino, Thomas Mignani, Antonina Limongi, Irene Ferraris, Matteo Orlandi, Marzia Rossato, Massimo Delledonne   +10 more
doaj   +1 more source

Cardiac involvement in patient-specific induced pluripotent stem cells of myotonic dystrophy type 1: unveiling the impact of voltage-gated sodium channels

Frontiers in Physiology, 2023
Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes muscle weakness and myotonia. In DM1 patients, cardiac electrical manifestations include conduction defects and atrial fibrillation.
Marion Pierre, Mohammed Djemai, Charles-Albert Chapotte-Baldacci, Valérie Pouliot, Jack Puymirat, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Chahine, Mohamed Chahine   +9 more
doaj   +1 more source

Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks

Frontiers in Physiology, 2021
The analysis of electrical impulse phenomena in cardiac muscle tissue is important for the diagnosis of heart rhythm disorders and other cardiac pathophysiology. Cardiac mapping techniques acquire local temporal measurements and combine them to visualize
Jan Lebert, Namita Ravi, Namita Ravi, Flavio H. Fenton, Jan Christoph   +4 more
doaj   +1 more source

Integration of Engineered “Spark-Cell” Spheroids for Optical Pacing of Cardiac Tissue

Frontiers in Bioengineering and Biotechnology, 2021
Optogenetic methods for pacing of cardiac tissue can be realized by direct genetic modification of the cardiomyocytes to express light-sensitive actuators, such as channelrhodopsin-2, ChR2, or by introduction of light-sensitized non-myocytes that couple ...
Christianne J. Chua, Julie L. Han, Weizhen Li, Wei Liu, Emilia Entcheva   +4 more
doaj   +1 more source

Voltage/Calcium Uncoupling Underlies Sustained Torsade de Pointes Ventricular Tachyarrhythmia in an Experimental Model of Long QT Syndrome

Frontiers in Physiology, 2021
BackgroundClinical experience showed that the majority of Torsade de Pointes (TdP) ventricular tachyarrhythmia (VT) in patients with long QT syndrome (LQTS) are self-terminating (ST), but the few that are non-self-terminating (NST) are potentially fatal.
Herman D. Himel, Michael Cupelli, Michael Cupelli, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir, Nabil El-Sherif, Nabil El-Sherif   +7 more
doaj   +1 more source