Results 81 to 90 of about 3,449,089 (306)
Design and analysis of a general data evaluation system based on social networks
EURASIP Journal on Wireless Communications and Networking, 2018 A social network is a social structure with a set of social actors and other social interactions between actors. The social network supports a set of methods to explain the structure of whole social entities as well as a variety of theories in these ...
Hongyan Li +3 more
doaj +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
eLife, 2018 Propagation of non-linear waves is key to the functioning of diverse biological systems. Such waves can organize into spirals, rotating around a core, whose properties determine the overall wave dynamics. Theoretically, manipulation of a spiral wave core
Rupamanjari Majumder +5 more
doaj +1 more source
Serbia city graphic 1:15,000 : Kragujevac / prepared ... by Defense Mapping Agency
, 1995 Ed. 3-DMA.Relief shown by contours and spot heights. "Map information as of 1993." "WGS 84." "Grid--1,000 meter UTM zone 34." "Printed by DMA 7-95." "This sheet falls within NK 34-02 and NL 34-11, 1501A 1:250,000 and 3183 II and 3182 I, M709, 1:50,000 ...
United States. Defense Mapping Agency
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Design and Use of an Optical Mapping System for the Study of Intracardiac Electrical Signaling
Indian Pacing and Electrophysiology Journal, 2012 Fluorescent optical mapping of electrically active cardiac tissues provides a unique method to examine the excitation wave dynamics of underlying action potentials.
Maneesh Shrivastav, PhD +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Large-Scale Structural Variation Detection in Subterranean Clover Subtypes Using Optical Mapping
Frontiers in Plant Science, 2018 We selected two genetically diverse subspecies of the Trifolium model species, subterranean clover cvs. Daliak and Yarloop. The structural variations (SVs) discovered by Bionano optical mapping (BOM) were validated using Illumina short reads.
Yuxuan Yuan +13 more
doaj +1 more source