Results 81 to 90 of about 3,285,258 (314)

On the use of stochastic differential geometry for non-equilibrium thermodynamics modeling and control

, 2012
We discuss the relevance of geometric concepts in the theory of stochastic differential equations for applications to the theory of non-equilibrium thermodynamics of small systems.
Muratore-Ginanneschi, Paolo
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Mitigating controller noise in quantum gates using optimal control theory [PDF]

Quantum
All quantum systems are subject to noise from the environment or external controls. This noise is a major obstacle to the realization of quantum technology. For example, noise limits the fidelity of quantum gates.
Aviv Aroch, Ronnie Kosloff, Shimshon Kallush   +2 more
doaj   +1 more source

Geometric reduction in optimal control theory with symmetries

, 2003
A general study of symmetries in optimal control theory is given, starting from the presymplectic description of this kind of system. Then, Noether's theorem, as well as the corresponding reduction procedure (based on the application of the Marsden ...
A. Echeverría-Enríquez, Abraham, Arnold, Blankenstein, Blankensteinand, Bloch, Bracket, Brocket, Carifiena, Cortés, Delgado, Echeverría-enríquez, Goldschmidt, Gotay, Gràcia, Grècia, Isidori, J. Marín-Solano, Jackubczyk, Jakubczyk, Jurdjevic, Jurdjevic, M.C. Muñoz-Lecanda, Marle, Marmo, Marsden, Martinez, Muñoz-Lecanda, Muñoz-Lecanda, N. Román-Roy, Nijmeijer, Respondek, Souriau, Sussmann, Sussmann, Sussmann, Torres, Van der Schaft, Warner   +38 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Optimal Control Theory for Undergraduates [PDF]

Dynamic optimization is widely used in financial economics, macroeconomics and resource economics. This is accounting for some tension between the undergraduate and graduate teaching of economics because most undergraduate programs still concentrate on ...
Ernst Juerg Weber
core   +1 more source

A Chebychev propagator for inhomogeneous Schr\"odinger equations

, 2009
We present a propagation scheme for time-dependent inhomogeneous Schr\"odinger equations which occur for example in optimal control theory or in reactive scattering calculations. A formal solution based on a polynomial expansion of the inhomogeneous term
Koch, Christiane P., Kosloff, Ronnie, Ndong, Mamadou, Tal-Ezer, Hillel   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Lipschitzian Regularity of the Minimizing Trajectories for Nonlinear Optimal Control Problems

, 2002
We consider the Lagrange problem of optimal control with unrestricted controls and address the question: under what conditions we can assure optimal controls are bounded?
Torres, Delfim F. M.
core   +2 more sources