Results 71 to 80 of about 93,510 (232)

Advanced Scientometric Analysis of Scientific Machine Learning and PINNs: Topic Modeling and Trend Analysis

IEEE Access
Scientific machine learning and physics-informed neural networks are novel conceptual approaches that integrate scientific knowledge with methods from data science and deep learning.
Frank Emmert-Streib, Shailesh Tripathi, Amer Farea, Olli Yli-Harja   +3 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Topic Modeling of Skincare Comments from Female Daily

Journal of Applied Informatics and Computing
The increasing popularity of skincare products in Indonesia has encouraged many consumers to seek and share information through online platforms. One of the most influential platforms is Female Daily, which provides a space for users to review and ...
Nabila Nabila, Chanifah Indah Ratnasari
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Yield of Brain MRI in Clinically Diagnosed Epilepsy in the Kingdom of Bhutan: A Prospective Study

Annals of Global Health, 2017
Background: People with epilepsy (PWE) in low- and middle-income countries may not access the health resources that are considered optimal for epilepsy diagnosis. The diagnostic yield of magnetic resonance imaging (MRI) has not been well studied in these
Veronica Bruno, Joshua P. Klein, Dechen Nidup, Damber K. Nirola, Lhab Tshering, Sonam Deki, Sarah J. Clark, Kristin A. Linn, Russell T. Shinohara, Chencho Dorji, Dili Ram Pokhrel, Ugyen Dema, Farrah J. Mateen, for the Bhutan Epilepsy Project   +13 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Design optimization of a circular enclosure with flexible fins: Fluid-Structure interaction and heat transfer analysis using rotating frame modeling

Case Studies in Thermal Engineering
This study optimizes heat transfer in a circular vessel containing cold and hot cylinders, a rotating frame, and flexible baffles designed to enhance thermal exchange. Optimized design of such topics improves the performance of heat exchangers.
Ali Qassim Abd Al-Hassan, Muneer A. Ismael, Mohammad Ghalambaz, Ali Chamkha, Mohamed Bechir Ben Hamida   +4 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

An Energy-Efficient Clustering Model for Wireless Sensor Networks Using Modified K-Means Algorithm

Proceedings of the International Conference on Applied Innovations in IT
Wireless Sensor Networks (WSNs) are becoming essential for many applications, ranging from smart cities to environmental monitoring. WSNs comprises a collection of deployed sensor nodes to execute specified objectives in a certain area.
Hassan Hadi Saleh, Abd Ali Hussein, Kilan Mohamed Hussein, Omar Abdul Kareem Mahmood, Shaymaa Jasim Mohammed, Mohammed Saleh Ali Muthanna   +5 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source