Results 71 to 80 of about 401,092 (295)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Ant lion optimizer for solving optimal reactive power dispatch problem in power systems

Engineering Science and Technology, an International Journal, 2017
This paper presents the use of a recent developed algorithm inspired by the hunting mechanism of antlions in nature, called ant lion optimizer (ALO) algorithm for solving optimal reactive power dispatch (ORPD) problem considering a large-scale power ...
Souhil Mouassa, Tarek Bouktir, Ahmed. Salhi   +2 more
doaj   +1 more source

Power system reactive power optimization based on MIPSO

Energy Procedia, 2012
AbstractIn order to improve power quality and reduce network losses, this paper proposes a modified immune particle swarm algorithm for power system reactive power optimization. To overcome the disadvantages in the traditional PSO algorithm about low accuracy and easy to fall into local optimal, MIPSO adopts sinusoidal changing inertia weight strategy ...
DingPing, Li, GuoLiang, Shen, WenDong, Guo, ZHi, Zhang, BaoNing, Hu, Wei, Gao   +5 more
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Reactive Power Optimization Using Quantum Particle Swarm Optimization [PDF]

Journal of Computer Science, 2012
Problem statement: The problem of controlling a power system is not an easy task; it is subjected to various constraints. There are at risks of voltage instability problems due to highly stressed operating conditions caused by increased load demand and other constraints in the power system network.
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Optimal Reactive Power Dispatch Planning Considering Voltage Deviation Minimization in Power Systems

Energies
Transmission lines in electrical power systems are studied and analyzed to improve the electrical system’s safety, stability, and optimal operation. Past research has proposed various optimization methods to address the problem of active and reactive ...
Orlando Álvarez, Diego Carrión, Manuel Jaramillo   +2 more
doaj   +1 more source

Decentralized Optimal Reactive Power Dispatch of Optimally Partitioned Distribution Networks

IEEE Access, 2018
This paper proposes a two-stage decentralized optimal reactive power dispatch (D-ORPD) framework, which considers the network partitioning influence in distributed optimization.
Peishuai Li, Zaijun Wu, Ke Meng, Guo Chen, Zhao Yang Dong   +4 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source