Results 81 to 90 of about 482,042 (298)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
POBE: A Computer Program for Optimal Design of Multi-Subject Blocked fMRI Experiments
Journal of Statistical Software, 2014 For functional magnetic resonance imaging (fMRI) studies, researchers can use multi-subject blocked designs to identify active brain regions for a certain stimulus type of interest.
Bärbel Maus, Gerard van Breukelen
doaj +1 more source
Известия высших учебных заведений. Поволжский регион:Технические науки, 2023 Background. Improving designs, expanding the range and increasing the production of quadrocopters are stable global trends. Progressive technical solutions, new materials, modern microelectronics are used in the designs of quadrocopters.
E.D. Kartashova
doaj +1 more source
Maximin and Bayesian optimal designs for regression models [PDF]
For many problems of statistical inference in regression modelling, the Fisher information matrix depends on certain nuisance parameters which are unknown and which enter the model nonlinearly.
Dette, Holger +2 more
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Optimal designs for statistical analysis with Zernike polynomials [PDF]
n.a.
Dette, Holger +2 more
core
Experimental designs for environmental valuation with choice-experiments: A Monte Carlo investigation [PDF]
, 2005 We review the practice of experimental design in the environmental economics literature concerned with choice experiments. We then contrast this with advances in the field of experimental design and present a comparison of statistical efficiency across ...
Ferrini, Silvia, Scarpa, Riccardo
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Optimal designs for dose finding studies with an active control [PDF]
, 2011 Dose finding studies often compare several doses of a new compound with a marketed standard treatment as an active control. In the past, however, research has focused mostly on experimental designs for placebo-controlled dose finding studies.
Benda, Norbert +3 more
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