Results 61 to 70 of about 17,832 (262)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Optimality Conditions for Nondifferentiable Multiobjective Semi-Infinite Programming Problems
Abstract and Applied Analysis, 2016 We have considered a multiobjective semi-infinite programming problem with a feasible set defined by inequality constraints. First we studied a Fritz-John type necessary condition. Then, we introduced two constraint qualifications and derive the weak and
D. Barilla, G. Caristi, A. Puglisi
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Nonsmooth analysis and optimization on partially ordered vector spaces
International Journal of Mathematics and Mathematical Sciences, 1992 Interval-Lipschitz mappings between topological vector spaces are defined and compared with other Lipschitz-type operators. A theory of generalized gradients is presented when both spaces are locally convex and the range space is an order complete vector
Thomas W. Reiland
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A Minimax-Program-Based Approach for Robust Fractional Multi-Objective Optimization
MathematicsIn this paper, by making use of some advanced tools from variational analysis and generalized differentiation, we establish necessary optimality conditions for a class of robust fractional minimax programming problems.
Henan Li, Zhe Hong, Do Sang Kim
doaj +1 more source
Necessary Conditions for Optimality for Stochastic Evolution Equations
Abstract and Applied Analysis, 2013 This paper is concerned with providing the maximum principle for a control problem governed by a stochastic evolution system on a separable Hilbert space.
AbdulRahman Al-Hussein
doaj +1 more source
Field- and concentration-dependent relaxation of magnetic nanoparticles and optimality conditions for magnetic fluid hyperthermia. [PDF]
Sci Rep, 2023 Ilg P, Kröger M.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Necessary optimality conditions for nonsmooth vector optimization problems
Mathematical Modelling and Analysis, 2003 In this paper we introduce a notion of generalized derivative for nonsmooth vector functions in order to obtain necessary optimality conditions for vector optimization problems.
Davide La Torre
doaj +1 more source