Unified Robust Necessary Optimality Conditions for Nonconvex Nonsmooth Uncertain Multiobjective Optimization. [PDF]
J Optim Theory Appl, 2022 Wang J, Li S, Feng M.
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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Abnormality in the Theory of Necessary Optimality Conditions
Известия Иркутского государственного университета: Серия "Математика", 2017 The problems of existence, non-uniqueness, abnormality of solutions arising from the using of necessary optimality conditions are discussed in terms of the extension principle and sufficient optimality conditions. Simple examples are used.
V.I. Gurman, M.M. Khrustalev
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Higher-Order Optimality Conditions in Set-Valued Optimization with Respect to General Preference Mappings. [PDF]
Set Valued Var Anal, 2022 Michalak A, Studniarski M.
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
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Robust Necessary Optimality Conditions for Nondifferentiable Complex Fractional Programming with Uncertain Data. [PDF]
J Optim Theory Appl, 2021 Chen J +4 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Optimality Conditions for a Nonsmooth Uncertain Multiobjective Programming Problem
Complexity, 2020 This note is devoted to the investigation of optimality conditions for robust approximate quasi weak efficient solutions to a nonsmooth uncertain multiobjective programming problem (NUMP).
Wenyan Han, Guolin Yu, Tiantian Gong
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
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