Results 71 to 80 of about 12,294,384 (368)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Necessary optimality conditions for nonsmooth vector optimization problems
Mathematical Modelling and Analysis, 2003 In this paper we introduce a notion of generalized derivative for nonsmooth vector functions in order to obtain necessary optimality conditions for vector optimization problems.
Davide La Torre
doaj +1 more source
Optimal control problem for 3D micropolar fluid equations
Electronic Journal of Qualitative Theory of Differential Equations, 2020 In this paper we study an optimal control problem related to strong solutions of 3D micropolar fluid equations. We deduce the existence of a global optimal solution with distributed control and, using a Lagrange multipliers theorem, we derive first-order
Exequiel Mallea-Zepeda, Luis Medina
doaj +1 more source
Approximate optimality conditions
, 2014 We propose in this paper a systematic study which is a variational approach of approximate optimality conditions in terms of Ekeland’s variational principle and some of its applications. Using a generalised differentiation(sub-differentiability) theory for non-smooth functions, new properties are then identified and approximate optimality conditions ...
SAHRAOUİ, R., BEDDANİ, A.
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Optimality Conditions and Duality in Nonsmooth Multiobjective Programs
Journal of Inequalities and Applications, 2010 We study nonsmooth multiobjective programming problems involving locally Lipschitz functions and support functions. Two types of Karush-Kuhn-Tucker optimality conditions with support functions are introduced.
Kim DoSang, Lee HyoJung
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Nonsmooth analysis and optimization on partially ordered vector spaces
International Journal of Mathematics and Mathematical Sciences, 1992 Interval-Lipschitz mappings between topological vector spaces are defined and compared with other Lipschitz-type operators. A theory of generalized gradients is presented when both spaces are locally convex and the range space is an order complete vector
Thomas W. Reiland
doaj +1 more source