Results 51 to 60 of about 933,480 (358)

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Personalising intravenous to oral antibiotic switch decision making through fair interpretable machine learning

Nature Communications
Antimicrobial resistance (AMR) and healthcare associated infections pose a significant threat globally. One key prevention strategy is to follow antimicrobial stewardship practices, in particular, to maximise targeted oral therapy and reduce the use of ...
William J. Bolton, Richard Wilson, Mark Gilchrist, Pantelis Georgiou, Alison Holmes, Timothy M. Rawson   +5 more
doaj   +1 more source

Barriers and facilitators to the uptake of new medicines into clinical practice: a systematic review

BMC Health Services Research, 2021
Background Implementation and uptake of novel and cost-effective medicines can improve patient health outcomes and healthcare efficiency. However, the uptake of new medicines into practice faces a wide range of obstacles.
Kristina Medlinskiene, Justine Tomlinson, Iuri Marques, Sue Richardson, Katherine Stirling, Duncan Petty   +5 more
doaj   +1 more source

Deterministic and robust optimisation strategies for metal forming proceesses [PDF]

, 2007
Product improvement and cost reduction have always been important goals in the metal forming industry. The rise of\ud Finite Element simulations for metal forming processes has contributed to these goals in a major way.
Bonte, M.H.A., Boogaard, A.H. van den, Huetink, J.   +2 more
core   +1 more source

Enhancement of speed and efficiency of an Internet based gear design optimisation [PDF]

, 2003
An internet-based gear design optimisation program has been developed for geographically dispersed teams to collaborate over the internet. The optimisation program implements genetic algorithm.
Amin, N, Su, D
core   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

Multi-Robot Exploration of Unknown Space Using Combined Meta-Heuristic Salp Swarm Algorithm and Deterministic Coordinated Multi-Robot Exploration

Sensors, 2023
Multi-robot exploration means constructing a finite map using a group of robots in an obstacle chaotic space. Uncertainties are reduced by distributing search tasks to robots and computing the best action in real time.
Ali El Romeh, Seyedali Mirjalili
doaj   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Towards individualised treatment of urinary tract infections

Communications Medicine
Monitoring host- and pathogen-specific biomarkers alongside drug levels at the site of infection offers promise for personalised antimicrobial therapy.
Ellen V. Stadler, Alison Holmes, Danny O’Hare, Timothy M. Rawson   +3 more
doaj   +1 more source

FREE SEARCH – A NOVEL HEURISTIC METHOD [PDF]

, 2003
Key words to describe the work: Evolutionary computing, Artificial Intelligence, Free Search. Key Results: Inspired from the nature new population-based algorithm applied to numerical optimisation. How does the work advance the state-of-the-art?: Novel
Littlefair, Guy, Penev, Kalin
core   +1 more source