Results 91 to 100 of about 300,025 (308)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Optimum load matching in direct-coupled photovoltaic power systems - application to resistive loads

, 1990
In this paper the load matching factor is used as a measure for the quality of load matching to the photovoltaic (PV) array. An optimization approach is used to solve the load matching problem with the objective of maximizing the load matching factor ...
Khouzam, Kamel Y.
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Effect of the enzyme concentration on the optimum temperature.

, 2019
A) Relative activity of Sfβgly during the assays at different temperatures in experiments performed using 280 nM Sfβgly and B) 85 nM Sfβgly. (purple cross) 29°C; (blue circle) 33°C; (blue diamond) 37°C; (red square) 42°C; (green triangle) 46°C.
Sandro R. Marana (560928), Vitor M. Almeida (4768668)   +1 more
core   +1 more source

Estimating the ability of plants to plastically track temperature-mediated shifts in the spring phenological optimum [PDF]

, 2017
One consequence of rising spring temperatures is that the optimum timing of key life history events may advance. Where this is the case, a population’s fate may depend on the degree to which it is able to track a change in the optimum timing either via ...
Hadfield, Jarrod, Christine J. Tansey, Jarrod D. Hadfield, Tansey, Christine, Albert B. Phillimore, Phillimore, Albert; id_orcid   +5 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Asymmetric adaptation of dryland vegetation to a warming and drying climate over two decades in Xinjiang, China: Evidence from satellite observations

International Journal of Applied Earth Observations and Geoinformation
Arid-zone vegetation may adapt to climate warming and increased precipitation by adjusting photosynthetic capacity and modifying its temperature–precipitation response.
Haiwei Zhang, Xuan Zhang, Fei Zhang, Jianghua Zheng, Jinming Yang, Longhui Li, Jia Song, Xu Ma   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Root temperature and growth of young tomato plants

, 1977
During recent years sophisticated techniques are applied in the glasshouse industry for the control of the glasshouse climate. Along with that development, extensive research programs were carried out to establish optimum conditions for growth.
Harssema, H.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source