Results 81 to 90 of about 300,025 (308)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Influence of temperature on the larval development of the edible crab Cancer pagurus

, 2009
The influence of temperature on larval survival and development was studied in the edible crab, Cancer pagurus, from a population off the Island of Helgoland, North Sea.
Keller, Martina, Thatje, S., Heilmayer, O., Anger, Klaus, Weiss, Monika, Heilmayer, Olaf, Anger, K., Brey, T., Brey, Thomas, Weiss, M.   +9 more
core   +1 more source

Experimental investigation of coupled thermo-mechanical behaviour of Kaolin clay [PDF]

E3S Web of Conferences
An experimental study regarding the thermo-mechanical behaviour of a Malaysian Kaolin is presented in this paper. Mercury intrusion porosimetry (MIP) tests have been performed on compacted samples with varying initial water contents. Samples compacted at
Kayser Timon, Baille Wiebke, Tafili Merita, Wichtmann Torsten   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Characterization of phospholipase B of Culex pipiens fatigans

Journal of Lipid Research, 1969
Phospholipase B has been found in the mosquito Culex pipiens fatigans, and some of its properties have been studied. The enzyme had a high optimum temperature (45°C) and broad alkaline pH optimum (8-9).
R. Hanumantha Rao, D. Subrahmanyam
doaj   +1 more source

Non-optimum temperature increases risk and burden of acute myocardial infarction onset: A nationwide case-crossover study at hourly level in 324 Chinese cities. [PDF]

EClinicalMedicine, 2022
Jiang Y, Hu J, Peng L, Li H, Ji JS, Fang W, Yan H, Chen J, Wang W, Xiang D, Su X, Yu B, Wang Y, Xu Y, Wang L, Li C, Chen Y, Zhao D, Kan H, Ge J, Huo Y, Chen R.   +21 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Water activity, solute and temperature modify growth and spore production of wild type and genetically engineered Aspergillus niger strains. [PDF]

, 2004
The effect of interactions of water activity (aw) (0.99–0.90), temperature (20, 30 and 35 °C) and modifying aw solute (glycerol, NaCl) on growth and sporulation of a wild-type strain of Aspergillus niger (W) and two genetically engineered lysozyme ...
Magan, Naresh, Aldred, David, Parra, Roberto, Archer, David B.   +3 more
core   +1 more source

A new method to evaluate temperature vs. pH activity profiles for biotechnological relevant enzymes

Biotechnology for Biofuels, 2017
Background Glycoside hydrolases are important for various industrial and scientific applications. Determination of their temperature as well as pH optima and range is crucial to evaluate whether an enzyme is suitable for application in a biotechnological
J. Herlet, P. Kornberger, B. Roessler, J. Glanz, W. H. Schwarz, W. Liebl, V. V. Zverlov   +6 more
doaj   +1 more source