Results 71 to 80 of about 300,025 (308)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Temperature sensitivity of soil carbon decomposition [PDF]
, 2013 The world's soils contain three times as much carbon as the atmosphere. Thus, any changes in this carbon pool may affect atmospheric CO₂ levels with implications for climate change.
Erhagen, Björn
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 2002 The power-time curves of growth of three strains of petroleum bacteria at different NaCl concentrations at 40.0 and 50.0 degreesC have been determined by using a 2277 Thermometric Thermal Activity Analyser. An equation of a power-time curve, ln[alphaP(K)/
Nan, ZD, Tan, ZC
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Tropical Agricultural Research, 2015 Maize (Zea mays L.) yields in Sri Lanka have been below its potential yield mainly due to biotic and abiotic stresses. This situation is likely to be aggravated in a changing climate in the future.
M.A.P.W.K. Malaviarachchi +5 more
doaj +1 more source
Optimization of Culture Conditions for Growth of Marine Phytoplankton
Journal of Tropical Life Science, 2020 The present study investigated the optimum levels of ambient temperature, salinity and light intensity for the growth of marine diatoms and microalgae. The marine diatoms Thalassiosira subtilis, Entomoneis paludosa and microalgae Isochrysis galbana were ...
Kunguma Kannika Maharajan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Optimum temperature for floral terpene emissions tracks the mean temperature of the flowering season
, 2021 Emissions of volatiles from leaves exhibit temperature dependence on maximums, but the optimum temperatures for the release of floral volatiles and the mechanism(s) of optimising these emissions have not been determined. We hypothesised that flowers have
Farré Armengol, Gerard +4 more
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