Results 1 to 10 of about 43,018 (315)

Optogenetics in Brain Research: From a Strategy to Investigate Physiological Function to a Therapeutic Tool [PDF]

Photonics, 2019
Dissecting the functional roles of neuronal circuits and their interaction is a crucial step in basic neuroscience and in all the biomedical field. Optogenetics is well-suited to this purpose since it allows us to study the functionality of neuronal ...
Elena Montagni, Francesco Resta, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone   +3 more
doaj   +2 more sources

Optogenetics: Background, Methodological Advances and Potential Applications for Cardiovascular Research and Medicine [PDF]

Frontiers in Bioengineering and Biotechnology, 2020
Optogenetics is an elegant approach of precisely controlling and monitoring the biological functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution by using optical system and genetic engineering technologies. The
Jyotsna Joshi, Michael Rubart, Wuqiang Zhu   +2 more
doaj   +3 more sources

Optogenetics and chemogenetics: key tools for modulating neural circuits in rodent models of depression [PDF]

Frontiers in Neural Circuits
Optogenetics and chemogenetics are emerging neuromodulation techniques that have attracted significant attention in recent years. These techniques enable the precise control of specific neuronal types and neural circuits, allowing researchers to ...
Shaowei Li, Jianying Zhang, Jiehui Li, Yajie Hu, Mingkuan Zhang, Haijun Wang   +5 more
doaj   +2 more sources

Optogenetics

Current Opinion in Ophthalmology, 2015
In this review, we will discuss the recent developments in optogenetics and their potential applications in ophthalmology to restore vision in retinal degenerative diseases.In recent years, we have seen major advances in the field of optogenetics, providing us with novel opsins for potential applications in the retina.
Duebel, Jens, Marazova, Katia, Sahel, José-Alain   +2 more
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Group-based, autonomous, individualized training and testing of long-tailed macaques (Macaca fascicularis) in their home enclosure to a visuo-acoustic discrimination task

Frontiers in Psychology, 2022
In recent years, the utility and efficiency of automated procedures for cognitive assessment in psychology and neuroscience have been demonstrated in non-human primates (NHP).
Jorge Cabrera-Moreno, Jorge Cabrera-Moreno, Jorge Cabrera-Moreno, Jorge Cabrera-Moreno, Lena Jeanson, Lena Jeanson, Marcus Jeschke, Marcus Jeschke, Marcus Jeschke, Marcus Jeschke, Antonino Calapai, Antonino Calapai, Antonino Calapai, Antonino Calapai   +13 more
doaj   +1 more source

Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporters

Cell Discovery, 2023
Naturally occurring fluorescent proteins (FPs) are the most widely used tools for tracking cellular proteins and sensing cellular events. Here, we chemically evolved the self-labeling SNAP-tag into a palette of SNAP-tag mimics of fluorescent proteins ...
Dasheng Zhang, Zhengda Chen, Zengmin Du, Bingkun Bao, Ni Su, Xianjun Chen, Yihui Ge, Qiuning Lin, Lipeng Yang, Yujie Hua, Shuo Wang, Xin Hua, Fangting Zuo, Ningfeng Li, Renmei Liu, Li Jiang, Chunyan Bao, Yuzheng Zhao, Joseph Loscalzo, Yi Yang, Linyong Zhu   +20 more
doaj   +1 more source

Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system

Nature Communications, 2022
The authors present a cage-based stand-alone platform for autonomous, standardized, and unsupervised training and testing of visuo-auditory-cued behaviours of common marmosets. The experiments do not require dietary restriction or social separation.
A. Calapai, J. Cabrera-Moreno, T. Moser, M. Jeschke   +3 more
doaj   +1 more source

Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors

Cell Regeneration, 2022
Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs.
Ting Li, Yejun Zou, Shuning Liu, Yi Yang, Zhuo Zhang, Yuzheng Zhao   +5 more
doaj   +1 more source

Optogenetics in plants [PDF]

New Phytologist, 2020
SummaryThe last two decades have witnessed the emergence of optogenetics; a field that has given researchers the ability to use light to control biological processes at high spatiotemporal and quantitative resolutions, in a reversible manner with minimal side‐effects.
Christie, John M., Zurbriggen, Matias D.
openaire   +3 more sources

A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice

Nature Communications, 2021
Pulsing cellular dynamics in genetic circuits have been shown to provide critical capabilities to cells in stress response, signaling and development.
Ting Li, Xianjun Chen, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye, Yi Yang   +9 more
doaj   +1 more source