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The Roles of Optogenetics and Technology in Neurobiology: A Review
Frontiers in Aging Neuroscience, 2022 Optogenetic is a technique that combines optics and genetics to control specific neurons. This technique usually uses adenoviruses that encode photosensitive protein. The adenovirus may concentrate in a specific neural region.
Wenqing Chen +13 more
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X-Optogenetics and U-Optogenetics: Feasibility and Possibilities [PDF]
Photonics, 2015 Optogenetics is an established technique that uses visible light to modulate membrane voltage in neural cells. Although optogenetics allows researchers to study parts of the brain like never before, it is limited because it is invasive, and visible light
Rachel Berry +3 more
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Applications and challenges of rhodopsin-based optogenetics in biomedicine
Frontiers in Neuroscience, 2022 Optogenetics is an emerging bioengineering technology that has been rapidly developed in recent years by cross-integrating optics, genetic engineering, electrophysiology, software control, and other disciplines.
Hanci Zhang +9 more
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Optogenetics and chemogenetics: key tools for modulating neural circuits in rodent models of depression [PDF]
Frontiers in Neural CircuitsOptogenetics and chemogenetics are emerging neuromodulation techniques that have attracted significant attention in recent years. These techniques enable the precise control of specific neuronal types and neural circuits, allowing researchers to ...
Shaowei Li +5 more
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Optogenetics: implications for Alzheimer’s disease research and therapy
Molecular Brain, 2022 Alzheimer’s disease (AD), a critical neurodegenerative condition, has a wide range of effects on brain activity. Synaptic plasticity and neuronal circuits are the most vulnerable in Alzheimer’s disease, but the exact mechanism is unknown.
Parsa Mirzayi +4 more
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Optogenetic manipulation of neural activity in C. elegans: from synapse to circuits and behavior [PDF]
, 2013 The emerging field of optogenetics allows for optical activation or inhibition of neurons and other tissue in the nervous system. In 2005 optogenetic proteins were expressed in the nematode C. elegans for the first time. Since then, C. elegans has served as a powerful platform upon which to conduct optogenetic investigations of synaptic function ...
Steven Husson +2 more
arxiv +3 more sources
High fidelity optogenetic control of individual prefrontal cortical pyramidal neurons in vivo [PDF]
F1000 Research 2012, 1:7, 2012 Precise spatial and temporal manipulation of neural activity in specific genetically defined cell populations is now possible with the advent of optogenetics. The emerging field of optogenetics consists of a set of naturally-occurring and engineered light-sensitive membrane proteins that are able to activate (e.g., channelrhodopsin-2, ChR2) or silence (
Shinya Nakamura +4 more
arxiv +3 more sources
The Development and Application of Optogenetics [PDF]
Annual Review of Neuroscience, 2011 Genetically encoded, single-component optogenetic tools have made a significant impact on neuroscience, enabling specific modulation of selected cells within complex neural tissues.
Lief E. Fenno +2 more
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Bioluminescence-Driven Optogenetics
Life, 2020 Bioluminescence-based technologies are among the most commonly used methods to quantify and visualise physiology at the cellular and organismal levels.
Macià Sureda-Vives, Karen S. Sarkisyan
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Optogenetics in Neural Systems [PDF]
Neuron, 2011 Both observational and perturbational technologies are essential for advancing the understanding of brain function and dysfunction. But while observational techniques have greatly advanced in the last century, techniques for perturbation that are matched to the speed and heterogeneity of neural systems have lagged behind. The technology of optogenetics
O. Yizhar +4 more
semanticscholar +4 more sources