Results 21 to 30 of about 58,764 (371)
Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans [PDF]
, 2012 The C. elegans nervous system is particularly well suited for optogenetic analyses of circuit function: Essentially all connections have been mapped, and light can be directed at the neuron of interest in the freely moving, transparent animals, while ...
Erbguth, Karen +4 more
core +13 more sources
Red Light Optogenetics in Neuroscience
Frontiers in Cellular Neuroscience, 2022 Optogenetics, a field concentrating on controlling cellular functions by means of light-activated proteins, has shown tremendous potential in neuroscience.
K. Lehtinen, M. Nokia, H. Takala
semanticscholar +1 more source
Optogenetics: Solving the Enigma of Sleep [PDF]
Sleep Medicine Research, 2018 Sleep is a crucial and evolutionarily conserved phenomenon, but the mechanisms that control sleep-wake behavior and underlie sleep disorders are not yet fully understood.
Victor James Drew, Jae Meen Lee, Tae Kim
doaj +1 more source
Optogenetics Illuminates Applications in Microbial Engineering.
Annual Review of Chemical and Biomolecular Engineering, 2022 Optogenetics has been used in a variety of microbial engineering applications, such as chemical and protein production, studies of cell physiology, and engineered microbe-host interactions.
Shannon M. Hoffman +2 more
semanticscholar +1 more source
Cell, 2010 Optogenetic methods use light to modulate the activities of target cells in vivo. By improving inter- and intracellular trafficking of light-sensitive switch proteins called opsins, Gradinaru et al. (2010) have developed a new generation of optogenetic tools capable of regulating the activity of targeted neurons with exquisite precision and efficiency.
Liu, Xu, Tonegawa, Susumu
openaire +4 more sources
Frontiers in Psychiatry, 2022 BackgroundsThe neural circuit mechanisms underlying depression remain unclear. Recently optogenetics has gradually gained recognition as a novel technique to regulate the activity of neurons with light stimulation.
Shanshan Lin +11 more
doaj +1 more source
A red light–responsive photoswitch for deep tissue optogenetics
Nature Biotechnology, 2022 Red light penetrates deep into mammalian tissues and has low phototoxicity, but few optogenetic tools that use red light have been developed. Here we present MagRed, a red light–activatable photoswitch that consists of a red light–absorbing bacterial ...
Yuto Kuwasaki +14 more
semanticscholar +1 more source
Emerging optogenetics technologies in biomedical applications
Smart Medicine, 2023 Optogenetics is a cutting‐edge technology that merges light control and genetics to achieve targeted control of tissue cells. Compared to traditional methods, optogenetics offers several advantages in terms of time and space precision, accuracy, and ...
Haozhen Ren +4 more
doaj +1 more source
Optogenetics in epilepsy [PDF]
Neurosurgical Focus, 2013 Optogenetics, the use of light to stimulate or inhibit neural circuits via viral transduction of protein channels, has emerged as a possible method of treating epilepsy. By introducing viral vectors carrying algal-derived cation or anion channels, known as opsins, neurons that initiate or propagate seizures may be silenced.
Cynthia A. Chestek +3 more
openaire +2 more sources
Optogenetics in primate cortical networks
Frontiers in Neuroanatomy, 2023 The implementation of optogenetics in studies on non-human primates has generally proven quite difficult, but recent successes have paved the way for its rapid increase.
Sam Merlin +2 more
doaj +1 more source