Results 41 to 50 of about 55,224 (387)

Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics

Neuroscience Bulletin, 2022
Pain is an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. The processing of pain involves complicated modulation at the levels of the periphery, spinal cord, and brain ...
Fang Guo, Yu Du, Feng-Hui Qu, Shi-Da Lin, Zhong Chen, Shihong Zhang   +5 more
semanticscholar   +1 more source

Optogenetics in epilepsy [PDF]

Neurosurgical Focus, 2013
Optogenetics, the use of light to stimulate or inhibit neural circuits via viral transduction of protein channels, has emerged as a possible method of treating epilepsy. By introducing viral vectors carrying algal-derived cation or anion channels, known as opsins, neurons that initiate or propagate seizures may be silenced.
Cynthia A. Chestek, J. Nicole Bentley, William C. Stacey, Parag G. Patil   +3 more
openaire   +2 more sources

Advances in Ophthalmic Optogenetics: Approaches and Applications

Biomolecules, 2022
Recent advances in optogenetics hold promise for vision restoration in degenerative eye diseases. Optogenetics refers to techniques that use light to control the cellular activity of targeted cells.
Philipp P. Prosseda, Matthew Tran, Tia J Kowal, Biao Wang, Yang Sun   +4 more
semanticscholar   +1 more source

Towards circuit optogenetics [PDF]

Current Opinion in Neurobiology, 2018
Optogenetics neuronal targeting combined with single-photon wide-field illumination has already proved its enormous potential in neuroscience, enabling the optical control of entire neuronal networks and disentangling their role in the control of specific behaviors. However, establishing how a single or a sub-set of neurons controls a specific behavior,
Chen, I-Wen, Papagiakoumou, Eirini, Emiliani, Valentina   +2 more
openaire   +5 more sources

Optogenetics and deep brain stimulation neurotechnologies [PDF]

, 2015
Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt, A Berndt, A Priori, AA Kuhn, AA Kuhn, AS Chuong, B Sauer, B Wingeier, BY Chow, BY Chow, C Bamann, D Luo, D Oesterhelt, D Oesterhelt, D Williams, ES Boyden, EY Uc, F Zhang, F Zhang, G Foffani, G Miesenbock, G Nagel, J Cavanaugh, J Mobley, J Volkmann, J Wells, J Wietek, JG Bernstein, JG Bernstein, JG Bernstein, JL Spudich, JL Spudich, JO Dostrovsky, JZ Tsien, L Bekar, L Madisen, LA Gunaydin, M Weinberger, M Weinberger, MC Rodriguez-Oroz, MJ Lehmkuhle, ML Welter, MM Doroudchi, O Yizhar, P Brown, P Silberstein, R Levy, R Levy, R Levy, R Waehler, S Zhao, TW Chen, VC Anderson, X Han, X Han, X Han, X Han, X Han, X Liu   +58 more
core   +2 more sources

Controlling protein stability with SULI, a highly sensitive tag for stabilization upon light induction

Nature Communications, 2023
Optogenetics tools for precise temporal and spatial control of protein abundance are valuable in studying diverse complex biological processes. In the present study, we engineer a monomeric tag of stabilization upon light induction (SULI) for yeast and ...
Miaowei Mao, Yajie Qian, Wenyao Zhang, Siyu Zhou, Zefeng Wang, Xianjun Chen, Yi Yang   +6 more
doaj   +1 more source

Photonic Nanojet‐Mediated Optogenetics

Advancement of science, 2022
Optogenetics has become a widely used technique in neuroscience research, capable of controlling neuronal activity with high spatiotemporal precision and cell‐type specificity.
Jinghui Guo, Yong Wu, Z. Gong, Xixi Chen, F. Cao, S. Kala, Z. Qiu, Xinyi Zhao, Jun-jiang Chen, Dongming He, Taiheng Chen, Rui Zeng, Jiejun Zhu, K. Wong, S. Murugappan, T. Zhu, Q. Xian, X. Hou, Y. Ruan, Baojun Li, Y. Li, Yao Zhang, Lei Sun   +22 more
semanticscholar   +1 more source

Step Sequence is a Critical Gait Parameter of Unilateral 6-OHDA Parkinson's Rat Models

Cell Transplantation, 2017
Parkinson's disease is a progressive neurological disorder, marked by the loss of dopaminergic neurons in the nigrostriatal pathway that leads to abnormal gait, rigidity, slowness of movement, and tremor.
Heather A. Baldwin, Pyry P. Koivula, Julie C. Necarsulmer, Keith W. Whitaker, Brandon K. Harvey   +4 more
doaj   +1 more source

Effects of electrical and optogenetic deep brain stimulation on synchronized oscillatory activity in Parkinsonian basal ganglia [PDF]

IEEE Trans Neural Syst Rehabil Eng 25:2188-2195, 2017, 2017
Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic stimulation is an effective experimental stimulation technique to affect pathological network dynamics.
arxiv   +1 more source

A red light–responsive photoswitch for deep tissue optogenetics

Nature Biotechnology, 2022
Red light penetrates deep into mammalian tissues and has low phototoxicity, but few optogenetic tools that use red light have been developed. Here we present MagRed, a red light–activatable photoswitch that consists of a red light–absorbing bacterial ...
Yuto Kuwasaki, Kazushi Suzuki, Gaigai Yu, Shota Yamamoto, Takahiro Otabe, Yuki Kakihara, M. Nishiwaki, Keita Miyake, K. Fushimi, Ramsey Bekdash, Yoshihiro Shimizu, R. Narikawa, Takahiro Nakajima, M. Yazawa, Moritoshi Sato   +14 more
semanticscholar   +1 more source