Results 51 to 60 of about 58,764 (371)
Optogenetics in Neural Systems [PDF]
Neuron, 2011 Both observational and perturbational technologies are essential for advancing the understanding of brain function and dysfunction. But while observational techniques have greatly advanced in the last century, techniques for perturbation that are matched to the speed and heterogeneity of neural systems have lagged behind. The technology of optogenetics
O. Yizhar +4 more
semanticscholar +4 more sources
Optogenetics and Chemogenetics [PDF]
, 2018 Optogenetics and chemogenetics provide the ability to modulate neurons in a type- and region-specific manner. These powerful techniques are useful to test hypotheses regarding the neural circuit mechanisms of general anesthetic end points such as hypnosis and analgesia.
Ken Solt +3 more
openaire +2 more sources
Keeping track of worm trackers [PDF]
, 2012 C. elegans is used extensively as a model system in the neurosciences due to its well defined nervous system. However, the seeming simplicity of this nervous system in anatomical structure and neuronal connectivity, at least compared to higher animals ...
Gottschalk, Alexander +3 more
core +1 more source
Studying Synaptic Connectivity and Strength with Optogenetics and Patch-Clamp Electrophysiology
International Journal of Molecular Sciences, 2022 Over the last two decades the combination of brain slice patch clamp electrophysiology with optogenetic stimulation has proven to be a powerful approach to analyze the architecture of neural circuits and (experience-dependent) synaptic plasticity in such
L. Linders +6 more
semanticscholar +1 more source
The Impact of Optogenetics on Regenerative Medicine
Applied Sciences, 2019 Optogenetics is a novel strategic field that combines light (opto-) and genetics (genetic) into applications able to control the activity of excitable cells and neuronal circuits.
Gianrico Spagnuolo +5 more
doaj +1 more source
Fighting against fast speckle decorrelation for light focusing inside live tissue by photon frequency shifting [PDF]
, 2020 Light focusing inside live tissue by digital optical phase conjugation (DOPC) has drawn increasing interest due to its potential biomedical applications in optogenetics, microsurgery, phototherapy, and deep-tissue imaging.
Cheng, Zhongtao +5 more
core +1 more source
Voltage imaging and optogenetics reveal behavior dependent changes in hippocampal dynamics
Nature, 2019 A technology that simultaneously records membrane potential from multiple neurons in behaving animals will have a transformative effect on neuroscience research1,2.
Yoav Adam +23 more
semanticscholar +1 more source
Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice
Nature Biotechnology, 2021 Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established.
C. Kathe +21 more
semanticscholar +1 more source
The Optogenetic Catechism [PDF]
Science, 2009 An emerging set of methods enables an experimental dialogue with biological systems composed of many interacting cell types—in particular, with neural circuits in the brain. These methods are sometimes called “optogenetic” because they use light-responsive proteins (“opto-”) encoded in DNA (“-genetic”).
openaire +3 more sources
Biosensors, 2021 The mammalian olfactory system has an amazing ability to distinguish thousands of odorant molecules at the trace level. Scientists have made great achievements on revealing the olfactory sensing mechanisms in decades; even though many issues need ...
Ping Zhu +6 more
doaj +1 more source