Results 51 to 60 of about 55,224 (387)
Three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT). [PDF]
, 2017 Optical methods capable of manipulating neural activity with cellular resolution and millisecond precision in three dimensions will accelerate the pace of neuroscience research. Existing approaches for targeting individual neurons, however, fall short of
Adesnik, Hillel +5 more
core +2 more sources
Optogenetic switching of migration of contractile cells [PDF]
Communications Physics 6:158 (2023), 2022 Cell crawling on flat substrates is based on intracellular flows of the actin cytoskeleton that are driven by both actin polymerization at the front and myosin contractility at the back. The new experimental tool of optogenetics makes it possible to spatially control contraction and thereby possibly also cell migration.
arxiv +1 more source
Rods progressively escape saturation to drive visual responses in daylight conditions
Nature Communications, 2017 Rod photoreceptors are thought to be saturated under bright light. Here, the authors describe the physiological parameters that mediate response saturation of rod photoreceptors in mouse retina, and show that rods can drive visual responses in photopic ...
Alexandra Tikidji-Hamburyan +14 more
doaj +1 more source
AAV1 is the optimal viral vector for optogenetic experiments in pigeons (Columba livia)
Communications Biology, 2021 Rook et al. establish a viral gene transfer system to perform optogenetics in pigeons. They deliver ChR2 via AAV1 into the visual entopallium and show its behavioral relevance for contrast perception, verifying the applicability of optogenetics in an ...
Noemi Rook +6 more
doaj +1 more source
Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review [PDF]
Journal of Yeungnam Medical Science, 2022 The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat
Haneol Ko, Sang-Pil Yoon
doaj +1 more source
Studying Synaptic Connectivity and Strength with Optogenetics and Patch-Clamp Electrophysiology
International Journal of Molecular Sciences, 2022 Over the last two decades the combination of brain slice patch clamp electrophysiology with optogenetic stimulation has proven to be a powerful approach to analyze the architecture of neural circuits and (experience-dependent) synaptic plasticity in such
L. Linders +6 more
semanticscholar +1 more source
Optogenetics, physiology, and emotions [PDF]
Frontiers in Behavioral Neuroscience, 2013 Optogenetics is a powerful tool for investigating causal links between neural circuits and behavior. In recent years, optogenetic studies have expanded into the emotional realm, elucidating new facts about the circuits that underlie anxiety, depression, and reward.
Antonello Bonci, Alexxai V. Kravitz
openaire +4 more sources
Precise multimodal optical control of neural ensemble activity. [PDF]
, 2018 Understanding brain function requires technologies that can control the activity of large populations of neurons with high fidelity in space and time. We developed a multiphoton holographic approach to activate or suppress the activity of ensembles of ...
Adesnik, Hillel +8 more
core +1 more source
A roadmap to integrate astrocytes into Systems Neuroscience. [PDF]
, 2020 Systems neuroscience is still mainly a neuronal field, despite the plethora of evidence supporting the fact that astrocytes modulate local neural circuits, networks, and complex behaviors. In this article, we sought to identify which types of studies are
De Pittà, Maurizio +7 more
core +2 more sources
The Impact of Optogenetics on Regenerative Medicine
Applied Sciences, 2019 Optogenetics is a novel strategic field that combines light (opto-) and genetics (genetic) into applications able to control the activity of excitable cells and neuronal circuits.
Gianrico Spagnuolo +5 more
doaj +1 more source