Results 71 to 80 of about 55,224 (387)
The optogenetic (r)evolution [PDF]
Molecular Genetics and Genomics, 2011 Optogenetics is a rapidly evolving field of technology that allows optical control of genetically targeted biological systems at high temporal and spatial resolution. By heterologous expression of light-sensitive microbial membrane proteins, opsins, cell type-specific depolarization or silencing can be optically induced on a millisecond time scale ...
Rein, M.L., Deussing, J.M.
openaire +3 more sources
A Point-process Response Model for Spike Trains from Single Neurons in Neural Circuits under Optogenetic Stimulation [PDF]
Stat Med. 2016; 35(3): 455-74, 2012 Optogenetics is a new tool to study neuronal circuits that have been genetically modified to allow stimulation by flashes of light. We study recordings from single neurons within neural circuits under optogenetic stimulation. The data from these experiments present a statistical challenge of modeling a high frequency point process (neuronal spikes ...
arxiv +1 more source
Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo [PDF]
, 2013 Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates a variety of essential processes in diverse cell types, functioning via cAMP-dependent effectors such as protein kinase A (PKA) and/or exchange proteins directly activated by cAMP (EPAC ...
Akbari +60 more
core +1 more source
Nature Communications, 2021 Optogenetics combined with electrical recording has emerged as a powerful tool for investigating causal relationships between neural circuit activity and function.
Liang Zou +6 more
semanticscholar +1 more source
Timing Control of Single Neuron Spikes with Optogenetic Stimulation [PDF]
, 2018 This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron'
Eckford, Andrew W. +3 more
core +2 more sources
Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. [PDF]
, 2020 Cold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure.
Ferro, Marc D +8 more
core
A Light Wand to Untangle the Myocardial Cell Network
Methods and Protocols, 2019 The discovery of optogenetics has revolutionized research in neuroscience by providing the tools for noninvasive, cell-type selective modulation of membrane potential and cellular function in vitro and in vivo. Rhodopsin-based optogenetics has later been
Tania Zaglia +2 more
doaj +1 more source
ACS Nano, 2019 Since the isolation of graphene in 2004, there has been an exponentially growing number of reports on layered two-dimensional (2D) materials for applications ranging from protective coatings to biochemical sensing.
Adam Bolotsky +7 more
semanticscholar +1 more source
Herald of the Russian Academy of Sciences, 2019 In this article the authors discuss electronic and optogenetic approaches for degenerative (blind) retina prosthesis as the main strategies for the restoration of vision to blind people. Primary attention is devoted to the prospects of developing retinal prostheses for the blind using modern optogenetic methods, and rhodopsins, which are photosensitive
M. A. Ostrovsky +3 more
openaire +3 more sources
Optogenetic Functional MRI [PDF]
Journal of Visualized Experiments, 2016 The investigation of the functional connectivity of precise neural circuits across the entire intact brain can be achieved through optogenetic functional magnetic resonance imaging (ofMRI), which is a novel technique that combines the relatively high spatial resolution of high-field fMRI with the precision of optogenetic stimulation.
Peter Lin +3 more
openaire +3 more sources