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Science Signaling, 2015
The store-operated calcium channel Orai1 is required for both the transport of calcium into milk and the ejection of milk during lactation.
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The store-operated calcium channel Orai1 is required for both the transport of calcium into milk and the ejection of milk during lactation.
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The CAR that drives Ca 2+ to Orai1
Science Signaling, 2016A Ca 2+ -accumulating region in Orai1 facilitates ion permeation and contributes to selectivity.
Archana, Jha, Shmuel, Muallem
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Orai1: a channel to safer antithrombotic therapy
Blood, 2009In this issue of Blood, Braun and colleagues identify Orai1 as the major component of the store-operated Ca2+ entry channel in platelets. Their findings have significance for the development of safer antithrombotic drugs.
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Up-regulation of Orai1 in murine allergic rhinitis
Histochemistry and Cell Biology, 2010Orai1 is an essential pore-forming subunit of the Ca(2+) release-activated Ca(2+) channels and plays a key role in the store-operated Ca(2+) entry. However, little is known about the function of this pathway in allergic airway diseases. In this study, we evaluated Orai1 expression in normal and allergic rhinitis (AR) mice airway and spleen.
Lin, Lin +4 more
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Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK
Cell Calcium, 2012STIM and Orai isoforms orchestrate store operated Ca2+ entry (SOCE) and thus cytosolic Ca2+ fluctuations following stimulation by hormones, growth factors and further mediators. Orai1 is a target of Nedd4-2, an ubiquitin ligase preparing several plasma membrane proteins for degradation.
Florian, Lang +2 more
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Orai1 trafficking in mammalian cells
Qatar Foundation Annual Research Forum Volume 2013 Issue 1, 2013Modulation of calcium homeostasis plays a key role in regulating fundamental cellular processes, including gene transcription, cell proliferation, differentiation, and apoptosis. Store-operated calcium entry (SOCE) is the major pathway in non-excitable cells for extracellular Ca2+ influx across the plasma membrane and is regulated by the content of the
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Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β
International Journal of Molecular Sciences, 2022Joel Nieto Felipe +2 more
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Functional differences in agonist‐induced plasma membrane expression of Orai1α and Orai1β
Journal of Cellular Physiology, 2023Joel Nieto Felipe +2 more
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