Results 21 to 30 of about 808,923 (313)

GENERAL ANALGESIA BY ORAL ADMINISTRATION [PDF]

BMJ, 1918
This report is in the nature of a preliminary communication based on animal experiments and a sufficient number of clinical cases to support the conclusions of the animal work. It will be seen that general analgesia in which there is loss of sensation, with or without loss of consciousness, can be established for otherwise painful dressings and for ...
J T, Gwathmey, H T, Karsner
openaire   +2 more sources

Effects of Aucklandia lappa Decne. Extract on Hair Growth in Depilated CL57BL/6 Mice

Korean Journal of Clinical Laboratory Science, 2021
Aucklandia lappa Decne., a traditional herbal medicine, has been used to treat various diseases, including asthma, coughs, rheumatism, and diarrhea. In the present study, the effects of the oral administration of Aucklandia lappa Decne. extract on hair
Joung-Hee Kim, Syng-Ook Lee, Gyoung Yeun Beik, Keuk-Jun Kim   +3 more
doaj   +1 more source

Recent Advances in Oral Peptide or Protein-Based Drug Liposomes

Pharmaceuticals, 2022
The high physiology and low toxicity of therapeutic peptides and proteins have made them a hot spot for drug development in recent years. However, their poor oral bioavailability and unstable metabolism make their clinical application difficult.
Jian Cui, Zhiwei Wen, Wei Zhang, Wei Wu
doaj   +1 more source

Sodium-glucose co-transporter 2 (SGLT2) inhibitors: a growing class of anti-diabetic agents

Drugs in Context, 2014
Although several treatment options are available to reduce hyperglycemia, only about half of individuals with diagnosed diabetes mellitus (DM) achieve recommended glycemic targets.
Eva M Vivian
doaj   +1 more source

Recent Progress in Diatom Biosilica: A Natural Nanoporous Silica Material as Sustained Release Carrier

Pharmaceutics, 2023
A drug delivery system (DDS) is a useful technology that efficiently delivers a target drug to a patient’s specific diseased tissue with minimal side effects.
Hayeon Lim, Yoseph Seo, Daeryul Kwon, Sunggu Kang, Jiyun Yu, Hyunjun Park, Sang Deuk Lee, Taek Lee   +7 more
doaj   +1 more source

Anti-Inflammatory Activity of Chlorogenic Acid on Macrophages: A Simplified Simulation of Pharmacokinetics Following Ingestion Using a Windup Syringe Pump

Applied Sciences, 2023
Cell-culture-based drug tests are usually performed in an instantaneous delivery manner. However, in vivo pharmacokinetic studies have shown a steady increase in the concentration of bioactive compounds in the plasma following oral administration, with ...
Lei Cao, Won Han, Sang Gil Lee, Joong Ho Shin   +3 more
doaj   +1 more source

Orally administrated Lactobacillus gasseri TM13 and Lactobacillus crispatus LG55 can restore the vaginal health of patients recovering from bacterial vaginosis

Frontiers in Immunology, 2023
Bacterial vaginosis (BV) is a common infection of the lower genital tract with a vaginal microbiome dysbiosis caused by decreasing of lactobacilli. Previous studies suggested that supplementation with live Lactobacillus may benefit the recovery of BV ...
Fengyuan Qi, Fengyuan Qi, Fengyuan Qi, Fengyuan Qi, Shangrong Fan, Shangrong Fan, Shangrong Fan, Chao Fang, Chao Fang, Lan Ge, Jinli Lyu, Jinli Lyu, Jinli Lyu, Zhuoqi Huang, Zhuoqi Huang, Zhuoqi Huang, Shaowei Zhao, Shaowei Zhao, Yuanqiang Zou, Yuanqiang Zou, Liting Huang, Liting Huang, Liting Huang, Xinyang Liu, Xinyang Liu, Xinyang Liu, Yiheng Liang, Yiheng Liang, Yiheng Liang, Yongke Zhang, Yongke Zhang, Yongke Zhang, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Liang Xiao, Xiaowei Zhang, Xiaowei Zhang, Xiaowei Zhang   +38 more
doaj   +1 more source

Genotoxic evaluation of polymeric nanoparticles

Frontiers in Genetics, 2015
An important strategy for optimizing the therapeutic efficacy of many conventional drugs is the development of polymeric nanoparticles (NPs), as it may expand their activities, reduce their toxicity, increase their bioactivity and improve biodistribution.
Tamara Iglesias Alonso
doaj   +1 more source

Oral Probiotic Expressing Human Ethanol Dehydrogenase Attenuates Damage Caused by Acute Alcohol Consumption in Mice

Microbiology Spectrum, 2023
Alcohol is an essential drug in human life with multiple medical functions, but excessive alcohol intake, even a single episode of binge drinking, can cause serious damage.
Xiaoxiao Jiang, Chunlong Yan, Hanlin Zhang, Li Chen, Rui Jiang, Kexin Zheng, Wanzhu Jin, Huijuan Ma, Xiaomeng Liu, Meng Dong   +9 more
doaj   +1 more source

Lipid Nanoparticles-Encapsulated YF4: A Potential Therapeutic Oral Peptide Delivery System for Hypertension Treatment

Frontiers in Pharmacology, 2019
Drugs are administered orally in the clinical treatment of hypertension. Antihypertensive peptides have excellent angiotensin converting enzyme inhibitors activity in vitro.
Shengnan Zhao, Jinhua Li, Jinhua Li, Yang Zhou, Yang Zhou, Lingjing Huang, Yanfei Li, Juanjuan Xu, Chunmei Fu, Xia Guo, Jian Yang   +10 more
doaj   +1 more source