Results 41 to 50 of about 5,189,653 (310)

Genotoxic evaluation of polymeric nanoparticles

Frontiers in Genetics, 2015
An important strategy for optimizing the therapeutic efficacy of many conventional drugs is the development of polymeric nanoparticles (NPs), as it may expand their activities, reduce their toxicity, increase their bioactivity and improve biodistribution.
Tamara Iglesias Alonso
doaj   +1 more source

Anti-Inflammatory Activity of Chlorogenic Acid on Macrophages: A Simplified Simulation of Pharmacokinetics Following Ingestion Using a Windup Syringe Pump

Applied Sciences, 2023
Cell-culture-based drug tests are usually performed in an instantaneous delivery manner. However, in vivo pharmacokinetic studies have shown a steady increase in the concentration of bioactive compounds in the plasma following oral administration, with ...
Lei Cao, Won Han, Sang Gil Lee, Joong Ho Shin   +3 more
doaj   +1 more source

Prevention of Infectious Mastitis by Oral Administration of Lactobacillus salivarius PS2 During Late Pregnancy.

Clinical Infectious Diseases, 2016
BACKGROUND Previous studies have shown that oral administration of lactobacilli can be an efficient approach to treat lactational infectious mastitis.
L. Fernández, Nívia Cárdenas, Rebeca Arroyo, S. Manzano, E. Jiménez, V. Martín, J. M. Rodríguez   +6 more
semanticscholar   +1 more source

Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]

, 2019
Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe, De Saeger, Sarah, Li, Yanshen, Li, Yi, Rao, Zhenghua, Sun, Feifei, Tan, Haiguang, Yang, Shupeng, Zhang, Huiyan, Zhou, Jinhui   +9 more
core   +1 more source

Lipid Nanoparticles-Encapsulated YF4: A Potential Therapeutic Oral Peptide Delivery System for Hypertension Treatment

Frontiers in Pharmacology, 2019
Drugs are administered orally in the clinical treatment of hypertension. Antihypertensive peptides have excellent angiotensin converting enzyme inhibitors activity in vitro.
Shengnan Zhao, Jinhua Li, Jinhua Li, Yang Zhou, Yang Zhou, Lingjing Huang, Yanfei Li, Juanjuan Xu, Chunmei Fu, Xia Guo, Jian Yang   +10 more
doaj   +1 more source

In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration

Drug Delivery, 2020
The purpose of this study is to evaluate in vitro and in vivo antitumor efficacy and subacute toxicity of triptolide (TP) prodrug, a conjugate between TP and carboxymethyl chitosan (CC).
Huahui Zeng, Xin Zhu, Qikang Tian, Yinyin Yan, Lan Zhang, Min Yan, Ruiqin Li, Xiaofang Li, Guoqiang Wang, Jinlian Ma, Yufang Su, Xiangbo Zhang, Linyu Ma, Zhenqiang Zhang, Xiangxiang Wu   +14 more
doaj   +1 more source

Oral Probiotic Expressing Human Ethanol Dehydrogenase Attenuates Damage Caused by Acute Alcohol Consumption in Mice

Microbiology Spectrum, 2023
Alcohol is an essential drug in human life with multiple medical functions, but excessive alcohol intake, even a single episode of binge drinking, can cause serious damage.
Xiaoxiao Jiang, Chunlong Yan, Hanlin Zhang, Li Chen, Rui Jiang, Kexin Zheng, Wanzhu Jin, Huijuan Ma, Xiaomeng Liu, Meng Dong   +9 more
doaj   +1 more source

Oral administration of pyrophosphate inhibits connective tissue calcification

EMBO Molecular Medicine, 2017
Various disorders including pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI), which are caused by inactivating mutations in ABCC6 and ENPP1, respectively, present with extensive tissue calcification due to reduced ...
D. Dedinszki, F. Szeri, E. Kozák, V. Pomozi, N. Tőkési, T. Mezei, Kinga Merczel, E. Letavernier, Ellie Tang, O. Le Saux, T. Arányi, K. van de Wetering, A. Váradi   +12 more
semanticscholar   +1 more source

Repeated Oral Administration of Oleanolic Acid Produces Cholestatic Liver Injury in Mice

Molecules, 2013
Oleanolic acid (OA) is a triterpenoid and a fantastic molecule with many beneficial effects. However, high-doses and long-term use can produce adverse effects. This study aimed to characterize the hepatotoxic potential of OA.
Yasha Xu, Yuan-Fu Lu, Xiao-Li Wan, Jie Liu   +3 more
doaj   +1 more source

Effects of Aucklandia lappa Decne. Extract on Hair Growth in Depilated CL57BL/6 Mice

Korean Journal of Clinical Laboratory Science, 2021
Aucklandia lappa Decne., a traditional herbal medicine, has been used to treat various diseases, including asthma, coughs, rheumatism, and diarrhea. In the present study, the effects of the oral administration of Aucklandia lappa Decne. extract on hair
Joung-Hee Kim, Syng-Ook Lee, Gyoung Yeun Beik, Keuk-Jun Kim   +3 more
doaj   +1 more source