Results 51 to 60 of about 5,189,653 (310)

Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium

Marine Drugs, 2022
The diverse therapeutic feasibility of the sea urchin-derived naphthoquinone pigment, Echinochrome A (Ech A), has been studied. Simple and noninvasive administration routes should be explored, to obtain the feasibility. Although the therapeutic potential
Ji-Su Ahn, Ye Young Shin, Su-Jeong Oh, Min-Hye Song, Min-Jung Kang, So Yeong Park, Phuong Thao Nguyen, Dang Khoa Nguyen, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Yoojin Seo, Byung-Chul Lee, Hyung-Sik Kim   +16 more
doaj   +1 more source

Sodium-glucose co-transporter 2 (SGLT2) inhibitors: a growing class of anti-diabetic agents

Drugs in Context, 2014
Although several treatment options are available to reduce hyperglycemia, only about half of individuals with diagnosed diabetes mellitus (DM) achieve recommended glycemic targets.
Eva M Vivian
doaj   +1 more source

Supplementation of an Anthocyanin-Rich Elderberry (Sambucus nigra L.) Extract in FVB/n Mice: A Healthier Alternative to Synthetic Colorants

Applied Sciences, 2022
Sambucus nigra L., popularly known as elderberry, is renowned for its amazing therapeutic properties, as well as its uses as a food source, in nutraceuticals, and in traditional medicine.
Tiago Azevedo, Tiago Ferreira, João Ferreira, Filipa Teixeira, Diana Ferreira, Rita Silva-Reis, Maria João Neuparth, Maria João Pires, Maria de Lurdes Pinto, Rui M. Gil da Costa, Margarida M. S. M. Bastos, Rui Medeiros, Luís Félix, Carlos Venâncio, Maria Inês Dias, Isabel Gaivão, Lillian Barros, Paula A. Oliveira   +17 more
doaj   +1 more source

4,4′-Diaponeurosporene-Producing Bacillus subtilis Increased Mouse Resistance against Salmonella typhimurium Infection in a CD36-Dependent Manner

Frontiers in Immunology, 2017
Deficient mucosal innate immunity is a hallmark of infectious diarrhea, such as Salmonella typhimurium (S. typhimurium)-induced gastroenteritis. Here, we report that oral administration of a 4,4′-diaponeurosporene-producing Bacillus subtilis (B.s-Dia ...
Qian Yang, Haofei Liu, Wenwen Xu, Qinghua Yu   +3 more
doaj   +1 more source

Dose–Response Study of Microcystin Congeners MCLA, MCLR, MCLY, MCRR, and MCYR Administered Orally to Mice

Toxins, 2021
Microcystins are common freshwater cyanobacterial toxins that affect liver function. The toxicities of five microcystin congeners (microcystin-LA (MCLA), MCLR, MCLY, MCRR, and MCYR) commonly observed in harmful algal blooms (HABs) were evaluated in BALB ...
Neil Chernoff, Donna Hill, Johnsie Lang, Judith Schmid, Amy Farthing, Hwa Huang   +5 more
doaj   +1 more source

The Aβ Containing Brain Extracts Having Different Effects in Alzheimer’s Disease Transgenic Caenorhabditis elegans and Mice

Frontiers in Aging Neuroscience, 2018
Background: The deposition of β-sheet rich amyloid in senile plaques is a pathological hallmark of Alzheimer’s disease (AD), which is thought to cause neuronal dysfunction.
Yufang Yang, Mo Wang, Ping Yang, Zishan Wang, Li Huang, Jing Xu, Wei Wang, Mei Yu, Liping Bu, Jian Fei, Fang Huang   +10 more
doaj   +1 more source

Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products

Pharmaceutics, 2020
Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a parent drug in the body. In the past, prodrugs were used as a last option; however, nowadays, prodrugs are considered already in the early stages of drug ...
Milica Markovic, Shimon Ben-Shabat, Arik Dahan   +2 more
doaj   +1 more source

Challenges and opportunities in current vaccine technology and administration: A comprehensive survey examining oral vaccine potential in the United States

Human Vaccines & Immunotherapeutics, 2022
This study provides a snapshot of the current vaccine business ecosystem, including practices, challenges, beliefs, and expectations of vaccine providers.
S. Indu Rupassara, John W. Kindt Jr, Nazmul Kazi, Indika Kahanda   +3 more
doaj   +1 more source

Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver

PLoS ONE, 2015
Although periodontitis has been implicated as a risk factor for various systemic diseases, the precise mechanisms by which periodontitis induces systemic disease remain to be elucidated.
Mayuka Nakajima, Kei Arimatsu, Tamotsu Kato, Y. Matsuda, T. Minagawa, N. Takahashi, H. Ohno, K. Yamazaki   +7 more
semanticscholar   +1 more source

Converting cyclosporine A from intravenous to oral administration in hematopoietic stem cell transplant recipients and the role of azole antifungals [PDF]

, 2018
Purpose: Cyclosporine A (CsA) is the most widely used immunosuppressive agent after a hematopoietic stem cell transplantation (HSCT). Although recommendations for CsA dose conversion from intravenous to oral administration differ from 1:1 to 1:3, most ...
Andrews, L.M. (Louise), Atiq, F. (Ferdows), Broers, A.E.C. (Annoek), Doorduijn, J.K. (Jeanette), Gelder, T. (Teun) van, Hameli, E. (Edon), Koch, B.C.P. (Birgit), Versmissen, J. (Jorie), Winter, B.C.M. (Brenda) de   +8 more
core   +1 more source