Results 11 to 20 of about 2,176,373 (353)

Phytosomes as a Plausible Nano-Delivery System for Enhanced Oral Bioavailability and Improved Hepatoprotective Activity of Silymarin

Pharmaceuticals, 2022
Silymarin, a phyto-constituent derived from the plant Silybum marianum, has been widely acknowledged for its hepatoprotective activities. Nevertheless, its clinical utility is adversely hampered by its poor water-solubility and its limited oral ...
Ravi Gundadka Shriram, Afrasim Moin, Hadil Faris Alotaibi, El-Sayed Khafagy, Ahmed Al Saqr, Amr Selim Abu Lila, Rompicherla Narayana Charyulu   +6 more
doaj   +2 more sources

Oral Bioavailability Enhancement of Raloxifene with Nanostructured Lipid Carriers

Nanomaterials, 2020
Raloxifene hydrochloride (RLX) shows poor bioavailability (90%). The objective of this study was to develop nanostructured lipid carriers (NLCs) for RLX to enhance its bioavailability.
Aditya Murthy, Punna Rao Ravi, Himanshu Kathuria, Shrinivas Malekar   +3 more
doaj   +2 more sources

Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability

Pharmaceutics, 2021
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration.
Thi-Thao-Linh Nguyen, Van-An Duong, Han-Joo Maeng   +2 more
doaj   +2 more sources

The influence of the gut microbiota on the bioavailability of oral drugs

Acta Pharmaceutica Sinica B, 2021
Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract.
Xintong Zhang, Ying Han, Wei Huang, Mingji Jin, Zhonggao Gao   +4 more
doaj   +2 more sources

Nanoemulsion-based delivery system for enhanced oral bioavailability and Caco-2 cell monolayers permeability of berberine hydrochloride

Drug Delivery, 2017
Berberine hydrochloride (BBH) has a variety of pharmacological activities such as antitumor, antimicrobial, anti-inflammation, and reduce irritable bowel syndrome. However, poor stability and low oral bioavailability limited its usage.
Yong-Jiang Li, Xiong-Bin Hu, Xiu-Ling Lu, De-Hua Liao, Tian-Tian Tang, Jun-Yong Wu, Da-Xiong Xiang   +6 more
doaj   +2 more sources

Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles

Drug Delivery, 2017
Fisetin (FST), a potent anticancer phytoconstituent, exhibits poor aqueous solubility and hence poor bioavailability. The aim of the present study is to improve the oral bioavailability of FST by encapsulating into PLGA NPs (poly-lactide-co-glycolic acid
Amrita Kadari, Sagarika Gudem, Hitesh Kulhari, Murali Mohan Bhandi, Roshan M. Borkar, Venkata Ramana Murthy Kolapalli, Ramakrishna Sistla   +6 more
doaj   +2 more sources

HobPre: accurate prediction of human oral bioavailability for small molecules

Journal of Cheminformatics, 2022
Human oral bioavailability (HOB) is a key factor in determining the fate of new drugs in clinical trials. HOB is conventionally measured using expensive and time-consuming experimental tests.
Min Wei, Xudong Zhang, Xiaolin Pan, Bo Wang, Changge Ji, Yifei Qi, J. H. Zhang   +6 more
semanticscholar   +1 more source

Nanovesicles-Mediated Drug Delivery for Oral Bioavailability Enhancement

International Journal of Nanomedicine, 2022
Bioavailability is an eternal topic that cannot be circumvented by peroral drug delivery. Adequate blood drug exposure after oral administration is a prerequisite for effective treatment.
Yuehong Ren, Linghui Nie, Shiping Zhu, Xingwang Zhang   +3 more
semanticscholar   +1 more source

Nanomedicine for increasing the oral bioavailability of cancer treatments

Journal of Nanobiotechnology, 2021
Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications ...
A. Parodi, Polina Buzaeva, Daria Nigovora, Alexey V Baldin, Dmitry Kostyushev, V. Chulanov, L. Savvateeva, A. Zamyatnin   +7 more
semanticscholar   +1 more source

Sodium Alginate/Chitosan-Coated Liposomes for Oral Delivery of Hydroxy-α-Sanshool: In Vitro and In Vivo Evaluation

Pharmaceutics, 2023
Background: Hydroxy-α-Sanshool (HAS) possesses various pharmacological properties, such as analgesia and regulating gastrointestinal function. However, the low oral bioavailability of HAS has limited its oral delivery in clinical application. Methods and
Fengming Tan, Huan Li, Kai Zhang, Lulu Xu, Dahan Zhang, Yang Han, Jing Han   +6 more
doaj   +1 more source