New IMB16-4 Nanoparticles Improved Oral Bioavailability and Enhanced Anti-Hepatic Fibrosis on Rats
Pharmaceuticals, 2022 Liver fibrosis is challenging to treat because of the lack of effective agents worldwide. Recently, we have developed a novel compound, N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamido) benzamide referred to as IMB16-4.
Xia Niu +5 more
doaj +1 more source
Absolute oral bioavailability of ciprofloxacin [PDF]
Antimicrobial Agents and Chemotherapy, 1986 We evaluated the absolute bioavailability of ciprofloxacin, a new quinoline carboxylic acid, in 12 healthy male volunteers. Doses of 200 mg were given to each of the volunteers in a randomized, crossover manner 1 week apart orally and as a 10-min intravenous infusion.
G L, Drusano +5 more
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Cyclosporine Absorption Following Orthotopic Liver Transplantation [PDF]
, 1986 Blood concentrations of cyclosporine were determined in adult and pediatric patients following orthotopic liver transplantation to quantitate cyclosporine blood clearance and oral absorption.
Beveridge +20 more
core +2 more sources
The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs
International Journal of Nanomedicine, 2020 Oral administration has been the most common therapeutic regimen in various diseases because of its high safety, convenience, lower costs, and high compliance of patients. However, susceptible in hostile gastrointestinal (GI) environment, many drugs show
Yuanyuan Wang +5 more
semanticscholar +1 more source
Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]
, 2019 Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe +9 more
core +1 more source
Pharmacokinetics and bioavailability of oral ifosfamide [PDF]
Journal of Cancer Research and Clinical Oncology, 1986 The bioavailability of oral N,3-bis(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide (ifosfamide) (500-mg gelatine capsules) was investigated in 18 patients with bronchogenic carcinoma. Oral and intravenous (Holoxan) ifosfamide was applicated in a randomized sequence on days 1 and 3 at a dose of 1 g/m2 (n = 12) and 2 g/m2 (n = 6 ...
T, Wagner, P, Drings
openaire +2 more sources
Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential [PDF]
, 2016 The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin.
Anand, Sridhar +5 more
core +2 more sources
Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]
, 2019 Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair +57 more
core +2 more sources
Oral Bioavailability of Atenolol
Journal of International Medical Research, 1989 The bioavailability of two formulations of atenolol was compared in an open, randomized crossover study. Each film-coated tablet contained 100 mg of active drug. The plasma concentrations of atenolol were determined using a newly developed and specific high-performance liquid chromatography procedure.
H, Vergin, V, Nitsche
openaire +2 more sources
Pharmaceutics, 2020 Ingestion is the preferred way for drug administration. However, many drugs have poor oral bioavailability, warranting the use of injections. Extracellular vesicles (EVs) from cow milk have shown potential utility in improving oral drug bioavailability ...
Greta Carobolante +3 more
doaj +1 more source