A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates
Asian Journal of Pharmaceutical Sciences, 2019 Monocarboxylate transporter 1 (MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the development of oral prodrugs.
Yixin Sun +7 more
doaj +1 more source
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis [PDF]
, 2011 Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is ...
AA Poltera +45 more
core +7 more sources
Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid
Applied Sciences, 2020 Ellagic acid, a polyphenolic compound present in fruit and berries, has recently been the object of extensive research for its antioxidant activity, which might be useful for the prevention and treatment of cancer, cardiovascular pathologies, and ...
G. Zuccari +5 more
semanticscholar +1 more source
Prediction of absolute bioavailability of medicines in children: based on predicted pediatric clearance from adults [PDF]
Exploration of Drug ScienceAim: The objective of this study was to evaluate the predictive performance of a proposed method to predict absolute bioavailability of medicines in children (infants to adolescents).
Iftekhar Mahmood
doaj +1 more source
Microbiology Spectrum, 2023 Macozinone (MCZ; PBTZ169) is a first-in-class antituberculosis clinical-stage benzothiazinone-based drug candidate. Although its efficacy and safety have been strongly proven in several preclinical and clinical studies, the physicochemical and ...
Angela Koryakova +5 more
doaj +1 more source
Journal of Chemical Information and Modeling, 2020 In-silico prediction of human oral bioavailability is a relevant tool for the selection of potential drug candidates and for the rejection of those molecules with less probability of success during the early stages of drug discovery and development ...
Gabriela Falcón-Cano +2 more
semanticscholar +1 more source
Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit [PDF]
, 2013 Cephalexin is a first generation cephalosporin widely used in rabbits. Its spectrum includes Pasteurella multocida and Staphylococcus aureus. These bacteria, together with Bordetella bronchiseptica, are the main cause of respiratory infections.
Albarellos, Gabriela Alejandra +2 more
core +2 more sources
Recent advances in improving oral drug bioavailability by cocrystals [PDF]
BioImpacts, 2018 Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy.
Shahram Emami +3 more
doaj +1 more source
Oral liquid antipsychotic formulation in the treatment of psychosis [PDF]
, 2013 This article discusses oral liquid antipsychotics as a treatment option to either oral tablets or injection formulation. It discusses bioavailability, treatment in emergencies and the potential merits of using oral liquid preparations in terms of ...
Bressington, D., Mutsatsa, S.
core +1 more source
Curcumin: Recent Advances in the Development of Strategies to Improve Oral Bioavailability.
Annual Review of Food Science and Technology, 2019 Substantial human and preclinical studies have shown that curcumin, a dietary compound from turmeric, has a variety of health-promoting effects including but not limited to antioxidant, antimicrobial, anti-inflammatory, and anticancer actions.
Katherine Z. Sanidad +4 more
semanticscholar +1 more source