Results 51 to 60 of about 2,176,373 (353)

Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]

, 2015
Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu, Oga, Enoche Florence, Sekine, Shuichi, Shitara, Yoshihisa   +3 more
core   +1 more source

Research Progress on Oral Nano-formulation to Deliver Astaxanthin

Shipin gongye ke-ji
Astaxanthin is a fat-soluble lutein carotenoid with good antioxidant, anti-inflammatory and immunomodulatory activities. However, its poor oral bioavailability lead to limited clinical application.
Chen ZHONG, Mei LIU, Yan GAO, Kefeng XU, Ying WANG   +4 more
doaj   +1 more source

Bioavailability Enhancement and Formulation Technologies of Oral Mucosal Dosage Forms: A Review

Pharmaceutics
The oral mucosa is a versatile surface for drug administration, supporting both local and systemic therapies. Many active substances are effectively absorbed in the oral cavity, offering an alternative to enteral administration by bypassing the harsh ...
Ildikó Bácskay, Petra Arany, Pálma Fehér, Liza Józsa, Gábor Vasvári, Dániel Nemes, Ágota Pető, Dóra Kósa, Ádám Haimhoffer, Zoltán Ujhelyi, Dávid Sinka   +10 more
doaj   +1 more source

Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]

, 2012
Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair, Amjesh R, Sugunan V.S.   +2 more
core   +2 more sources

Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins

Acta Pharmaceutica Sinica B, 2019
In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs.
Ying Han, Zhonggao Gao, Liqing Chen, Lin Kang, Wei Huang, Mingji Jin, Qiming Wang, You Han Bae   +7 more
doaj   +1 more source

A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption [PDF]

, 2012
Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo ...
Adibkia, Khosro, Barzegar-Jalali, Azim, Barzegar-Jalali, Mohammad, Mohammadi, Ghobad, Mohammadi, Kaivan, Nokhodchi, Ali, Valizadeh, Hadi   +6 more
core   +3 more sources

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability

Pharmaceutics, 2020
Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution rates in aqueous environments such as the luminal fluids of the gastrointestinal tract.
J. H. Van Der Merwe, J. Steenekamp, D. Steyn, J. Hamman   +3 more
semanticscholar   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Prediction of Oral Bioavailability in Rats: Transferring Insights from in Vitro Correlations to (Deep) Machine Learning Models Using in Silico Model Outputs and Chemical Structure Parameters

Journal of Chemical Information and Modeling, 2019
Oral administration of drug products is a strict requirement in many medical indications. Therefore, bioavailability prediction models are of high importance for prioritization of compound candidates in the drug discovery process.
S. Schneckener, Sergio Grimbs, Jessica Hey, S. Menz, Maren Osmers, Steffen Schaper, A. Hillisch, A. Göller   +7 more
semanticscholar   +1 more source