Results 71 to 80 of about 124,757 (203)

The Skin Prick Test is Not Useful in the Diagnosis of the Immediate Type Food Allergy Tolerance Acquisition

Allergology International, 2014
Background: : Some studies have been reported about positioning of SPT in the diagnosis of food allergy. On the other hand, it is not yet clear about the positioning of SPT in the diagnosis of tolerance acquisition of the immediate type food allergy ...
Takanori Imai, Noriyuki Yanagida, Mika Ogata, Takatsugu Komata, Morimitsu Tomikawa, Motohiro Ebisawa   +5 more
doaj   +1 more source

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

Advanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto, Emily Tsang, Marie Karen Tracy Hong Lin, Luca Mannino, Kurt V. Gothelf, Anja Boisen   +5 more
wiley   +1 more source

Phenotypes of Food Allergies in Patients with Atopic Dermatitis Aged Under 24 Months: A Multicenter Study

Diagnostics
Background: Atopic dermatitis (AD) and food allergy (FA) are common allergic diseases in early childhood. AD may be concomitant with FA, particularly in young children.
Mujde Tuba Cogurlu, Metin Aydogan, Ozlem Cavkaytar, Pinar Uysal, Hazal Cansu Culpan, Nalan Yakici, Zeynep Hizli Demirkale, Erdem Topal, Hasan Yuksel, Sezin Aydemir, Nursen Cigerci Gunaydin, Cigdem Aydogmus, Sukru Cekic, Emre Akkelle, Tuba Tuncel, Isil Eser Simsek, Mustafa Arga, Zeynep Ülker Altinel, Fatih Kaplan, Ayca Kiykim, Ayse Suleyman, Nermin Guler, Esra Yucel, Haluk Cokugras, Nihat Sapan, Hikmet Tekin Nacaroglu, Adem Yasar, Yakup Yesil, Gonca Hancioglu, Recep Sancak, Mehmet Sarper Erdogan, Oner Ozdemir, Cevdet Ozdemir, Fazil Orhan   +33 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Timing of initial symptom onset during milk and wheat challenges: A retrospective study

Immunity, Inflammation and Disease
Background Allergic reactions to milk appear sooner than those to hen's eggs, irrespective of the total dose of the oral food challenges (OFCs) and type of matrices.
Noriyuki Yanagida, Takanori Minoura, Sakura Sato, Kyohei Takahashi, Ken‐ichi Nagakura, Kiyotake Ogura, Takaaki Itonaga, Yoko Miura, Naoko Fusayasu, Motohiro Ebisawa   +9 more
doaj   +1 more source