Results 111 to 120 of about 9,443,204 (302)

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

pH‐Responsive Nanoplatform‐Mediated Lipid Hijacking and Metabolic Collapse for Synergistic Starvation‐Immunotherapy

Advanced Science, EarlyView.
A pH‐responsive ZIF‐8/2‐DG@Cu‐TA nanoplatform orchestrates multifaceted metabolic disruption for synergistic starvation‐immunotherapy. Acid‐triggered 2‐DG release blocks glycolysis, while Zn2+ overload induces mitochondrial dysfunction. Concurrently, Cx43‐mediated gap junctions redirect lipid droplets from tumor cells to cancer‐associated fibroblasts ...
Xianlong Zong, Haochen Yao, Danyang Shen, Furu Gong, Zixuan Wang, Haoyang Qin, Yang Yang, Ruirui Qiao, Yongjuan Li, Rui Li   +9 more
wiley   +1 more source

Influence of Hypoglycemia During The 100-G Oral Glucose Tolerance Test on Obstetrics Outcomes

Gynecology Obstetrics & Reproductive Medicine, 2008
OBJECTIVES: We aimed to investigate the impact of hypoglycemia during 100-g oral glucose tolerance test on perinatal outcomes. STUDY DESIGN: Obstetrics records of 411 pregnants who delivered singletons at our institution were reviewed.
İlknur İnegöl Gümüş, Feridun Karakurt, Ayşe Kargılı, Neslihan Carda Seçkin, Hasan Kafalı, Nilgün Öztürk Turhan   +5 more
doaj  

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

UNIVERSAL VS SELECTIVE SCREENING OF GESTATIONAL DIABETES MELLITUS BY ORAL GLUCOSE TOLERANCE TEST AT 24-28 WEEKS PREGNANCY

Pakistan Armed Forces Medical Journal, 2019
Objective: To compare universal screening of pregnant ladies for Gestational Diabetes Mellitus (GDM) with selective high risk screening by one step Oral Glucose Tolerance Test (OGTT) at 24-28 weeks pregnancy. Study Design: Comparative cross-sectional
Humaira Tariq, Asifa Siraj, Tariq Sarfraz, Asma Ansari, Ayesha Arif   +4 more
doaj   +2 more sources

Glucose values during oral glucose tolerance test (OGTT) in the presence and absence of metformin.

, 2015
Shown are mean ± standard deviation for A) blood glucose (mmol/L) prior to and during the SUGAR-MGH oral glucose tolerance test (OGTT) stratified by participants who took no metformin doses (blue dashed line with blue circles) and participants who took ...
Alisa K. Manning (110227), Amelia Lanier (713061), Sabina Q. Khan (713064), Richard W. Grant (713075), Andrew Taylor (135110), Varinderpal Kaur (713069), Chunmei Huang (124731), Maegan Harden (713070), Ling Chen (25698), Liana K. Billings (713053), Allan F. Moore (713068), Natalia Colomo (590447), Rachel J. Ackerman (713063), Laurel Garber (713066), Rebecca R. Fanelli (713060), Margo S. Hudson (713077), Geoffrey A. Walford (713051), Alicia M. Hernandez (713059), Jaclyn Davis (713057), Janet Lo (713073), Rosa Bui (713065), Katherine R. Littleton (713058), Bindu Chamarthi (713055), Allison Goldfine (713076), A. Sofia Warner (713056), Deborah Wexler (713071), Jose C. Florez (114792), Rita M. McCarthy (713072), Paul Huang (229892), Elliot S. Stolerman (713067), Marlene Fernandez (713054), Jennifer N. Todd (713052), Corinne Barbato (713062), Melissa K. Thomas (713074)   +33 more
core   +1 more source

Injectable Peptide‐Based Functional Amyloid Hydrogels as Tunable Depots for Sustained Drug Delivery

Advanced Science, EarlyView.
An injectable and tunable peptide‐based functional amyloid hydrogel provides sustained insulin release while preserving insulin stability and bioactivity. The hydrogel enables prolonged glycemic regulation in vivo, exhibits excellent biocompatibility, and shows no detectable IAPP and α‐Syn heterologous cross‐seeding, highlighting its potential as a ...
Ranjit Shaw, Niyamat M. A. Chimthanawala, Shouvik Manna, Sadhana Sathaye, Samir K. Maji   +4 more
wiley   +1 more source