Results 91 to 100 of about 9,443,204 (302)

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Oral glucose tolerance test for standard diet group during treatment phase.

Oral glucose tolerance test for standard diet group during treatment phase.
Peter W. Mwangi (18071426), Charles G. Githinji (18071429), Boniface M. Chege (18071423), Frederick Bukachi (18071432)   +3 more
core   +1 more source

Postprandial change in glucose level from baseline (mean ± SEM) during an oral glucose tolerance test.

, 2019
The fasting glucose level was used a baseline and the change in glucose level is plotted over time for 2.5 hours of the oral glucose tolerance test. Treatments for the oral glucose tolerance test include 50 gram glucose solution either alone (□), with ...
Sofia Feng Godinez (6519671), Ondulla T. Toomer (6519674), Jonathan C. Allen (526966), Lisa L. Dean (6519668), Lindsey M. Christman (6519665)   +4 more
core   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Anthropometry, glucose tolerance and insulin concentrations in South Indian children: relationships to maternal glucose tolerance during pregnancy

, 2005
Earlier studies have shown that individuals whose mothers were diabetic when they were in utero, have an increased risk of early obesity, and impaired glucose tolerance (lGT) and type 2 diabetes in adult life.
Krishnaveni, Ghattu Vedamurthy
core   +1 more source

Oral glucose tolerance test for LPHC diet group during treatment phase.

Oral glucose tolerance test for LPHC diet group during treatment phase.
Peter W. Mwangi (18071426), Charles G. Githinji (18071429), Boniface M. Chege (18071423), Frederick Bukachi (18071432)   +3 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Area under the curve for LPHC during the oral glucose tolerance test during treatment phase.

Area under the curve for LPHC during the oral glucose tolerance test during treatment phase.
Peter W. Mwangi (18071426), Charles G. Githinji (18071429), Boniface M. Chege (18071423), Frederick Bukachi (18071432)   +3 more
core   +1 more source

Relationship of circulating fetuin-A with the insulinogenic index, adjusted for age, sex and insulin sensitivity estimated from the oral glucose tolerance test, in subjects with normal glucose tolerance (N = 267; A) and impaired glucose tolerance (N = 91, B).

, 2014
Relationship of circulating fetuin-A with the insulinogenic index, adjusted for age, sex and insulin sensitivity estimated from the oral glucose tolerance test, in subjects with normal glucose tolerance (N = 267; A) and impaired glucose tolerance (N = 91,
Qi Sun (127), Matthias B. Schulze (125913), Frank B. Hu (127167), Charlotte Jeppesen (413704), Susanne Ullrich (193452), Hans-Georg Joost (106886), Fritz Schick (176974), Norbert Stefan (83540), Jürgen Machann (176966), Andreas Fritsche (36362), Felicia Gerst (538634), Heiner Boeing (23585), Hans-Ulrich Häring (36363)   +12 more
core   +1 more source

Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation‐Associated Paraptosis‐Like Cell Death in Colorectal Cancer

Advanced Science, EarlyView.
This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song, Sikei Kam, Jingyi Liu, Rui Lv, Xucheng Huo, Zhanghan Chen, Yuelun Dong, Shilun Cai, Bing Li, Ruobing Ren, Yunshi Zhong, Mingyan Cai   +11 more
wiley   +1 more source