Results 71 to 80 of about 9,443,204 (302)

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Myths and methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research

Experimental Physiology
Accurate measurements of glycaemic control and the underpinning regulatory mechanisms are vital in human physiology research. Glycaemic control is the maintenance of blood glucose concentrations within optimal levels and is governed by physiological ...
Elizabeth Wrench, Daren A. Subar, Theodoros M. Bampouras, Robert M. Lauder, Christopher J. Gaffney   +4 more
doaj   +1 more source

Levels of blood glucose and blood insulin during an oral glucose tolerance test.

, 2013
A) Blood glucose levels during an oral glucose tolerance test in male wt mice (open circles) and male hSAA1 mice (filled squares) fed with HFD. B) Blood glucose area under the curve (AUC) in male mice fed with HFD.
Kajsa Sjöholm (351309), Sofie Ahlin (351308), Bob Olsson (307393), Maja Olsson (351306), Per-Arne Svensson (157540)   +4 more
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Evaluation of patient satisfaction following oral glucose tolerance test

Northwestern Medical Journal
Aim: Diabetes mellitus (DM) is a common metabolic disease. Early diagnosis of diabetes prevents the increase in mortality and morbidity due to complications.
Püren Gökbulut, Habib Bilen, Emin Murat Akbaş, Çigdem Özdemir, Volkan Gökbulut, Gönül Koç   +5 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Oral glucose tolerance test.

, 2014
A; Fasting blood insulin, glucose levels and insulin resistance index (glucose (mM) x insulin (ng/ml)) and B; oral glucose tolerance test in WT mice fed SAT HFD (n = 8, filled bars, filled square) or PUFA HFD (n = 8, open bars, open square) and in Gpr120
Virginia M. Stone (679348), Xiufeng Xu (428514), Leonard H. Storlien (679350), Sofia Lundin (679346), Gerhard Böttcher (483183), David M. Smith (155808), Noel G. Morgan (679349), Mohammad Bohlooly-Y (217638), Mikael Bjursell (274867), Daniel Lindén (483184), Ralf Nilsson (679347), Jan Oscarsson (42119), Therése Admyre (5659573), Yan Y. Lam (175707)   +13 more
core   +1 more source

Metabolite profile deviations in an oral glucose tolerance test-A comparison between lean and obese individuals.

, 2014
While impaired glucose tolerance diagnosed by the oral glucose tolerance test (OGTT) is a common trait in obese individuals, less is known about changes in levels of other metabolites.
Mulder, Hindrik, Filipsson, Karin, Ridderstråle, Martin, Geidenstam, Nina, Danielsson, Anders, Spégel, Peter, Mulder, Hindrik,, Filipsson, Karin,, Danielsson, Anders,, Geidenstam, Nina,, Ridderstråle, Martin,, Lund University., Spégel, Peter,   +12 more
core   +2 more sources

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source