Results 81 to 90 of about 138,961 (205)

Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review [PDF]

, 2018
Pancreatic cancer has a dismal prognosis particularly in patients presenting with unresectable tumors. We performed a bibliometric analysis of clinical trials for pancreatic cancer conducted between 2014-2016 focusing on patients that presented with ...
Biankin, Andrew V., Khachigian, Levon M., Parish, Christopher R., Sheahan, Anjali V.   +3 more
core   +1 more source

Antioxidant Activity and Hypoallergenicity of Egg Protein Matrices Containing Polyphenols from Citrus Waste

Antioxidants
This study reports on the interactions of egg proteins, which represent a major health concern in food allergy, with polyphenols obtained from orange and lemon peels.
María Victoria Gil, Nuria Fernández-Rivera, Gloria Gutiérrez-Díaz, Jorge Parrón-Ballesteros, Carlos Pastor-Vargas, Diana Betancor, Carlos Nieto, Pedro Cintas   +7 more
doaj   +1 more source

Remembering the forgotten child: the role of immune checkpoint inhibition in patients with human immunod eficiency virus and cancer. [PDF]

, 2019
Patients with human immunodeficiency virus (HIV) infection have a high risk of developing virally-mediated cancers. These tumors have several features that could make them vulnerable to immune checkpoint inhibitors (ICIs) including, but not limited to ...
Adashek, Jacob J, Galanina, Natalie, Junior, Pedro Nazareth Aguiar, Kurzrock, Razelle   +3 more
core  

Oral Immunotherapy (OIT): A Personalized Medicine

Medicina, 2019
Oral Immunotherapy (OIT), a promising allergen-specific approach in the management of Food Allergies (FA), is based on the administration of increasing doses of the culprit food until reaching a maintenance dose.
Francesca Mori, Simona Barni, Giulia Liccioli, Elio Novembre   +3 more
doaj   +1 more source

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]

, 2018
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.
Abnousian, Arbi, Bluestone, Jeffrey A, DuPage, Michel, Fong, Lawrence, Harwin, Tory, Mahuron, Kelly, Pagani, Massimiliano, Pai, Chien-Chun, Quiros, Jason, Ranzani, Valeria, Rosenblum, Michael D, Silveria, Stephanie, Van Gool, Frederic, Wang, David, Young, Arabella   +14 more
core   +2 more sources

Peanut Genotypes with Reduced Content of Immunogenic Proteins by Breeding, Biotechnology, and Management: Prospects and Challenges

Plants
Peanut allergies affect millions of people worldwide, often causing life-threatening reactions and necessitating strict avoidance. Recent advancements in oral immunotherapy, such as Palforzia™, and IgE-mediated treatments (e.g., Xolair), have improved ...
Tariq Alam, Sachin Rustgi
doaj   +1 more source

Oral immunotherapy with enteric-coated capsules for allergic rhinitis caused by house dust mites

Frontiers in Allergy
BackgroundOral immunotherapy (OIT) is a promising allergen-specific approach in the management of food allergy; however, studies on OIT for allergic rhinitis (AR) have rarely been reported. The purpose of this study is to evaluate the efficacy and safety
Han-Zhong Zhang, Wei Xie, Wen-Cheng Zhou, Jian Chen, Ying Wang, Yuan-Yuan Zhu, Ting-Huan Wen, Lei Cheng, Lei Cheng   +8 more
doaj   +1 more source

Recent advances in food allergen immunotherapy [PDF]

Clinical and Experimental Pediatrics
Food allergies can pose significant risks and profoundly impact the quality of life of children and their families, making them a major public health concern. Allergen avoidance has been the traditional mainstay of treatment; however, recent research has
You Hoon Jeon, Edwin H. Kim
doaj   +1 more source

Myostatin inhibition with orally administered Lactobacillus casei expressing a modified human myostatin protein: functional benefits and translational potential in advanced Duchenne muscular dystrophy

Frontiers in Neurology
BackgroundDuchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder that requires novel therapeutic approaches beyond dystrophin restoration.
Jiwon Lee, Ju-A Kim, Yena Oh, Kwang Kim, Kwang Kim, Jeehun Lee   +5 more
doaj   +1 more source

Study of induction of Tolerance to Oral Peanut: a randomised controlled trial of desensitisation using peanut oral immunotherapy in children (STOP II)

Efficacy and Mechanism Evaluation, 2014
Background: Peanut allergy is a common disease that causes severe and fatal food allergic reactions. Currently, the best treatment is avoidance as repeated reactions can occur.
Katherine Anagnostou, Sabita Islam, Yvonne King, Loraine Foley, Laura Pasea, Chris Palmer, Simon Bond, Pamela Ewan, Andrew Clark   +8 more
doaj   +1 more source