Results 101 to 110 of about 1,913,005 (248)
ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential
iNew Medicine, EarlyView.ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Setmelanotide is a melanocortin‐4 receptor agonist approved for the treatment of rare forms of genetic obesity. Through off‐target activation of the melanocortin‐1 receptor, it may induce cutaneous pigmentation changes; however, data regarding its effects on melanocytic nevi remain limited.
Martina Cavicchi +5 more
wiley +1 more source
Oral malignant melanoma: A silent killer?
Journal of Indian Society of Periodontology, 2011 Oral malignant melanomas are extremely rare lesions and occur commonly in the maxillary gingiva more frequently on the palate with fewer incidences in the mandibular gingiva. Though these lesions are biologically aggressive, they often go unnoticed since
Ashvini Padhye, Jovita D′souza
doaj +1 more source
Plasma Cell Mucositis: A 20‐Year Retrospective Review at a Tertiary Center
JEADV Clinical Practice, EarlyView.ABSTRACT Background Plasma cell mucositis (PCM) is a rare, chronic inflammatory condition of mucosal surfaces that is likely underdiagnosed and underreported, with limited data on its clinical characteristics, extracavitary involvement, and treatment outcomes.
Miguel A. Aristizabal‐Torres +4 more
wiley +1 more source
Pembrolizumab‐Induced Subacute Cutaneous Lupus Erythematosus: A Case Report
JEADV Clinical Practice, EarlyView.ABSTRACT Subacute cutaneous lupus erythematosus (SCLE) is an increasingly recognized cutaneous immune‐related adverse event of immune checkpoint inhibitors. We report an 83‐year‐old woman who developed pruritic annular and polycyclic plaques 10 weeks after starting pembrolizumab for oropharyngeal squamous cell carcinoma.
Sebastiano Posenato +5 more
wiley +1 more source
Oral malignant melanoma: A rare malignancy
CHRISMED Journal of Health and Research, 2015 Primary malignant melanoma of the oral cavity is a rare neoplasm. It is very rare aggressive neoplasm arising from a benign melanocytic lesion or de novo from melanocytes within normal skin or mucosa.
L S Vagish Kumar
doaj +1 more source
Malignant Melanoma of Nose and Paranasal Sinuses: 2 Case Reports [PDF]
, 2010 Malignant melanoma is one of the rare and highly aggressive diseases of the sinonasal cavity. High index of suspicion is required for diagnosis as the patient usually presents with non specific signs and symptoms.
Gupta, N +9 more
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Oral potentially malignant disorders: is malignant transformation predictable and preventable? [PDF]
, 2014 Leukoplakia is the most common potentially malignant disorder of the oral mucosa. The prevalence is approxi - mately 1% while the annual malignant transformation ranges from 2% to 3%.
Van der Waal, Isaäc, van der Waal, I.
core +1 more source
EHR‐Integrated Synoptic Operative Reporting for Head and Neck Oncologic Surgery
The Laryngoscope, EarlyView.EHR‐integrated synoptic operative templates for head and neck oncologic surgery was developed and implemented at a tertiary academic cancer center. Departmental adherence rose from 49% to nearly 80% over 6 months, and 94.5% of reviewed cases met targets for complete, internally consistent documentation. The resulting structured data dictionary provides
Miriam N. Lango +14 more
wiley +1 more source
Malignant melanoma of the oral cavity
Indian Journal of Dental Research, 2006 Oral malignant melanoma is a rare disease. The common sites of its occurrence are the palate and gingiva with the maxillary arch being affected 80% of the time.
Ebenezer Jagadish
doaj