Results 111 to 120 of about 1,913,005 (248)

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Primary mucosal melanoma: A case report

Journal of Craniomaxillofacial Research, 2017
Malignant melanoma is an aggressive malignancy of melanocytes affecting both skin and mucosa. Primary oral melanoma occurs 0.2-8% of all melanomas and accounts for 0.5% of all oral malignancies.
Fereshteh Baghai, Sedigheh Rahrotaban, Ata Garajei, Fatemeh Pirzadeh, Samira Derakhshan   +4 more
doaj  

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Current Status and Molecular Mechanisms of Resistance to Immunotherapy in Oral Malignant Melanoma. [PDF]

Int J Mol Sci, 2023
Usta SZ, Uchihashi T, Kodama S, Kurioka K, Inubushi T, Shimooka T, Sugauchi A, Seki S, Tanaka S.   +8 more
europepmc   +1 more source

Oral malignant melanoma of the lower jaw-a case report with immunohistochemical investigations. [PDF]

Ecancermedicalscience, 2023
Tamgadge S, Pereira T, Date A, Kalimuthu P, Tamgadge A.   +4 more
europepmc   +1 more source

A scalable workflow for sensitive detection and genomic profiling of tumour cells in lymph nodes from FFPE tissue

The Journal of Pathology, EarlyView.
Abstract Accurate detection of lymph node (LN) metastases is critical for prognosis and surgical decision‐making in head and neck squamous cell carcinoma (HNSCC) and other epithelial cancers. Standard histopathology examines only a small fraction of LN tissue, limiting sensitivity for micrometastases and isolated tumour cells.
Tristan Bergmann, Marianne Hölbling, Monica Sudarsanam, Christiane Driemel, Maximilian E Daniels, Joanna Swierz, Sandra Jaschinski, Maximilian Seidl, Norbert R Kübler, Wolfram T Knoefel, Rui PL Neves, Karl C Sproll, Nikolas H Stoecklein   +12 more
wiley   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Amelanotic Melanoma - A case report with review of literature

Journal of Indian Academy of Oral Medicine and Radiology, 2007
Oral malignant melanoma is a rare disease. Amelanotic melanoma is a subtype of cutaneous melanoma with little or no pigmentation. True AMM are rare and there may be some pigmentation at the periphery of the lesion.
R Kamala, R Gopakumar, Subhas Babu, S Giridhar Naidu, Vidya AjiIa, Karthik Hegde   +5 more
doaj  

Primary Malignant Melanoma of the Endometrium: A Case Report

Case Reports in Oncology
Introduction: Malignant melanoma most commonly occurs in the skin. Primary malignant melanoma of endometrium is quite rare. Its diagnosis depends on clinical characteristics and pathological examination. It usually exhibits high degree of tumor histology,
Xiuting Shi, Jie Shi, Yanli Li, Xin Li, Xuemei Hu, Han Gao   +5 more
doaj   +1 more source