Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
User-created persona: Namibian rural Otjiherero speakers [PDF]
, 2015 Persona is a communicative artefact for usability that currently functions under the umbrella of User-Centred Design (UCD). Since we argue usability methods differ across cultures, this project presents a cross-cultural research probe on persona ...
Cabrero, Daniel G.
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
"Revolution? What Revolution?" Successes and limits of computing technologies in philosophy and religion [PDF]
, 2004 Computing technologies like other technological innovations in the modern West are inevitably introduced with the rhetoric of "revolution". Especially during the 1980s (the PC revolution) and 1990s (the Internet and Web revolutions), enthusiasts ...
Ess, Charles
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Codes and Hypertext: the Intertextuality of International and Comparative Law [PDF]
, 2008 The field of information studies reveals gaps in the literature of international and comparative law as part of interdisciplinary and textual studies. To illustrate the kind of theoretical and text-based work that could be done, this essay provides an ...
Raisch, Marylin J
core +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Review of: "Predictive factors of relapse after dose reduction of oral 5-aminosalicylic acid in patients with ulcerative colitis in the remission phase" [PDF]
, 2021 Grant E. Barber
openalex +1 more source
The whole Bible painted in our houses : Visual Narrative and Religious Polemic in Early Lutheran Art [PDF]
, 2003 (Excerpt) In his discussion of the psychodynamics of orality, the Jesuit linguist and philosopher Walter Ong writes that \u27\u27the interiorizing force of the oral word relates in a special way to the sacral, to the ultimate concerns of existence.
Torvend, Samuel
core +2 more sources