Results 91 to 100 of about 2,471,598 (337)

Savage Desert, American Garden: citrus labels and the selling of California, 1877-1929 [PDF]

open access: yes, 2008
In 1877, a year after the railroad reached Southern California, the first shipment of California oranges left the Los Angeles groves of William Wolfskill, bound for St. Louis, Missouri.
Knight Lozano, Henry
core  

Reducir la Necesidad de Educación Compensatoria Post-secundaria al Emplear la Auto-eficacia para Identificar a los Adolescentes Afroamericanos e Hispanos menos Preparados [PDF]

open access: yes, 2013
Introduction. Postsecondary remedial education is a major problem for Higher Education affecting retention rates, degree completion rates and cost of enrollment.
Orange, Carolyn
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

The high-frequency backscattering angular response of gassy sediments: Model/data comparison from the Eel River Margin, California [PDF]

open access: yes, 2002
A model for the high-frequency backscatter angular response of gassy sediments is proposed. For the interface backscatter contribution we adopted the model developed by Jackson et al. @J. Acoust. Soc. Am. 79, 1410–1422 ~1986!#, but added modifications to
Driscoll, Neal   +3 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Austrian higher education institutions' idiosyncrasies and technology transfer system [PDF]

open access: yes, 2008
The aim of this paper is to present the findings of a PhD research (Heinzl, 2007) conducted on the Universities of Applied Sciences in Austria. The research is to establish an idiosyncrasy model for Universities of Applied Sciences in Austria showing the
Heinzl, J   +3 more
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

A value oriented conceptual model for innovation in local government [PDF]

open access: yes, 2007
The political rhetoric that accompanied the introduction of eGovernment expected it to produce innovation in the way government agencies conducted themselves with citizen and business alike.
Elliman, T   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

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